U100
乌拉地尔 盐酸盐
solid
别名:
6-[[3-[4-（o-甲氧苯基）-1-哌嗪基] 丙基] 氨基]-1,3-二甲基尿嘧啶 盐酸盐
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关于此项目
经验公式（希尔记法）:
C20H29N5O3 · HCl
化学文摘社编号:
分子量:
423.94
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
form
solid
color
white
solubility
H2O: soluble 25 mg/mL, clear, colorless to very faintly yellow
SMILES string
Cl[H].COc1ccccc1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2
InChI
1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChI key
KTMLZVUAXJERAT-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), HTR1A(3350)
General description
肾上腺受体 α1a 基因 (ADRA1A) 定位于人类染色体 8p21.2，编码 α-肾上腺素能受体。
Biochem/physiol Actions
α1-肾上腺素受体拮抗剂；5-HT1A 5-羟色胺受体部分激动剂；抗高血压。
肾上腺素受体 α1a 基因 (ADRA1A) 参与平滑肌收缩。全身血管如皮肤、胃肠系统、泌尿生殖系统、肾和脑的血管收缩也需要它。ADRA1A 在肝脏脂肪组织糖原分解和糖异生中起主要作用。对交感神经系统也起关键作用。
肾上腺素受体 α1a 基因 (ADRA1A) 参与平滑肌收缩。全身血管如皮肤、胃肠系统、泌尿生殖系统、肾和脑的血管收缩也需要它。ADRA1A 在肝脏脂肪组织糖原分解和糖异生中起主要作用。对交感神经系统也起关键作用。
Preparation Note
盐酸乌拉地尔溶于水，浓度为 25 mg/mL，得到澄清、无色至非常淡黄色溶液。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
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Experimental parasitology, 216, 107944-107944 (2020-07-04)
Evaluation of the murine isotype antibodies is essential in subunit vaccine development because inbred mouse strains with diverse genetic backgrounds respond different to recombinant proteins. In this regard, the main goal of this study was to measuring and comparing the
B N Prichard et al.
The American journal of cardiology, 64(7), 11D-15D (1989-08-15)
Investigations in animals indicate that urapidil has a number of actions that may be relevant to its antihypertensive effect. It has an alpha 1-blocking action, a weak beta 1-blocking effect, an interaction with a serotonin receptor and a central depression
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Medical microbiology and immunology, 207(5-6), 271-286 (2018-06-28)
Despite considerable efforts toward vaccine development over decades, there is no available effective vaccine against Plasmodium vivax. Thrombospondin-related adhesive protein of P. vivax (PvTRAP) is essential for sporozoite motility and invasions into mosquito's salivary gland and vertebrate's hepatocyte; hence, it
N Kolassa et al.
The American journal of cardiology, 63(6), 36C-39C (1989-02-02)
Current knowledge about the role of serotonin (5-HT) in central cardiovascular regulation is reviewed. Results from experiments with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) suggest that activation of somatodendritic 5-HT1A receptors in the medulla oblongata decreases the firing of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| U100-100MG | 04061832094137 |
| U100-500MG | 04061832086286 |
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