U101
5-Methylurapidil
solid
别名:
5-Methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
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关于此项目
经验公式（希尔记法）:
C21H31N5O3
化学文摘社编号:
分子量:
401.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C21H31N5O3.ClH/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4;/h5-6,8-9,22H,7,10-15H2,1-4H3;1H
SMILES string
Cl[H].COc1ccccc1N2CCN(CCCNC3=C(C)C(=O)N(C)C(=O)N3C)CC2
InChI key
WAZDYFHTLYHMKO-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: 0.4 mg/mL, 0.1 M HCl: 3.8 mg/mL
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
Application
5-Methylurapidil has been used for competitive binding in radioligand binding assays.
Biochem/physiol Actions
Selective α1A-adrenoceptor antagonist; antihypertensive.
Features and Benefits
This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
5-Methylurapidil is soluble in water at 0.4 mg/ml and is also soluble in 0.1 M HCl at 3.8 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Rocío Alcántara-Hernández et al.
Biochimica et biophysica acta, 1864(12), 2378-2388 (2017-09-11)
In LNCaP cells that stably express α
Caroline Putzke et al.
Cardiovascular research, 75(1), 59-68 (2007-03-29)
The outward current flowing through the two-pore domain acid-sensitive potassium channel TASK-1 (I(TASK)) and its inhibition via alpha1-adrenergic receptors was studied in rat ventricular cardiomyocytes. Quantitative RT-PCR experiments were carried out with mRNA from rat heart. Patch-clamp recordings were performed
Wesley B Asher et al.
Journal of chemical information and modeling, 47(5), 1906-1912 (2007-08-25)
In this study, we have developed a two model system to mimic the active and inactive states of a G-protein coupled receptor specifically the alpha1A adrenergic receptor. We have docked two agonists, epinephrine (phenylamine type) and oxymetazoline (imidazoline type), as
Kim Davenport et al.
BJU international, 98(3), 651-655 (2006-08-24)
To compare the in vitro human ureteric muscle response to calcium-channel and alpha-adrenoceptor antagonists, to determine the promoting factor for stone passage. Clinical trials suggest that stone passage in renal colic can be promoted by ureteric relaxation using these agents
Z Huang et al.
Journal of dental research, 85(3), 251-256 (2006-02-25)
alpha(1)-Adrenoceptor has been discovered to exist in many human tissues and mediates important physiological functions. The purpose of this study was to detect the expression, distribution, and function of alpha(1)-adrenoceptor subtypes in human submandibular glands. alpha(1A)- and alpha(1B)-Adrenoceptor mRNAs were
商品
Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.
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