U105
U-62066
solid
别名:
(±)-(5α,7α,8β)-3,4-Dichloro-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]benzeneacetamide mesylate salt, Spiradoline mesylate salt
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关于此项目
线性分子式:
C22H30Cl2N2O2 · CH3SO3H
化学文摘社编号:
分子量:
521.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
产品名称
U-62066, solid
InChI
1S/C22H30Cl2N2O2.CH4O3S/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26;1-5(2,3)4/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3;1H3,(H,2,3,4)/t19-,20-,22-;/m0./s1
SMILES string
CS(O)(=O)=O.CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)Cc4ccc(Cl)c(Cl)c4
InChI key
FHEZDPDAYTVKKG-JLBKCEDKSA-N
form
solid
color
white
solubility
H2O: 14 mg/mL
methanol: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... OPRK1(4986)
Biochem/physiol Actions
U-62066, also known as spiradoline, is a highly selective κ opioid receptor agonist. It exhibits analgesic and diuretic effects. Antitussive property of U-62066 is observed in rats.
Preparation Note
U-62066 is soluble in water at 14 mg/ml, but is insoluble in methanol.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M A Smith et al.
Behavioural pharmacology, 14(8), 641-647 (2003-12-11)
The purpose of the present study was to examine sensitivity to the antinociceptive effects of kappa opioids during chronic treatment with the nonselective opioid antagonist naltrexone. In a warm-water tail-withdrawal procedure, rats were restrained and the latencies to remove their
David A White et al.
Brain research bulletin, 76(6), 597-604 (2008-07-05)
The primary objective of this study was to determine whether pretreatment with kappa- and delta-opioid agonists potentiates naltrexone-induced suppression of water consumption following 24h of deprivation. This study also examined the temporal effects of agonist-induced antinociception using the tail-flick and
Jolan M Terner et al.
Behavioural pharmacology, 16(8), 665-670 (2005-11-16)
Although studies suggest that 2-(3,4-dichlorophenyl-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl) ethyl] acetamide (DIPPA) has transient kappa-opioid-mediated agonist effects followed by long-lasting kappa-antagonist effects, its behavioral and pharmacological actions have not been systematically examined and there is evidence suggesting that some of its effects are species
Action of kappa and Delta opioid agonists on premotor cardiac vagal neurons in the nucleus ambiguus.
X Wang et al.
Neuroscience, 129(1), 235-241 (2004-10-19)
Both enkephalin and dynorphin containing fibers are in close proximity to neurons in the nucleus ambiguus, including cardiac vagal neurons. Microinjection of Delta and kappa agonists into the nucleus ambiguus have been shown to evoke decreases in heart rate. Yet
U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market.
Baumann, et al.
Brain sciences, 10 (2020)
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