U111
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate
≥98% (HPLC), κ opioid receptor agonist, solid
别名:
trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C19H26Cl2N2O · HCl · xH2O
化学文摘社编号:
分子量:
405.79 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate, solid, ≥98% (HPLC)
SMILES string
O.Cl.CN([C@H]1CCCC[C@@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI key
UWPRPWMHQDPOFR-MPGISEFESA-N
InChI
1S/C19H26Cl2N2O.ClH.H2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H;1H2/t17-,18-;;/m0../s1
assay
≥98% (HPLC)
form
solid
optical activity
[α]22/D -39.0 to -32.0°, c = 0.5 in methanol(lit.)
storage condition
desiccated
color
white
solubility
H2O: 13 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... OPRK1(4986)
Application
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta).
Biochem/physiol Actions
Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.
Preparation Note
(−)-trans-(1S,2S)-U-50488 hydrochloride hydrate is soluble in water at 13 mg/ml.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Stephen M Johnson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 295(5), R1599-R1612 (2008-09-12)
For ectothermic vertebrates, such as reptiles, the effects of opioid receptor subtype activation on breathing are poorly understood. On the basis of previous studies on mammals and lampreys, we hypothesized that mu- and delta-opioid receptor (MOR and DOR, respectively) activation
Stereospecific inhibition of gastro-intestinal transit by κ-opioid agonists in mice.
Ramabadran, et al.
European Journal of Pharmacology, 155, 329-329 (1991)
D D Taub et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(2), 360-364 (1991-01-15)
Opioids and opioid peptides have been shown by numerous laboratories to modulate various parameters of the immune response, but little attention has been given to the type of opioid receptor that might be involved. This study focuses on the in
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