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安全信息

U116

Sigma-Aldrich

U-99194 maleate salt

≥98% (HPLC), solid

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别名:
5,6-Dimethoxy-2-(di-n-propylamino)indan maleate salt
经验公式（希尔记法）:
C17H27NO2 · C4H4O4
CAS号:
234757-41-6
分子量:
393.47
MDL编号:
MFCD01529985
PubChem化学物质编号:
24277946
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

solid

颜色

white

溶解性

H2O: >5 mg/mL

SMILES字符串

OC(=O)\C=C/C(O)=O.CCCN(CCC)C1Cc2cc(OC)c(OC)cc2C1

InChI

1S/C17H27NO2.C4H4O4/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;5-3(6)1-2-4(7)8/h11-12,15H,5-10H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

FSIQDESGRQTFNN-BTJKTKAUSA-N

基因信息

human ... DRD3(1814)

应用

U-99194 maleate has been used as a dopaminergic antagonist to study its effects on immobility episodes and yawning frequency in rats.

生化/生理作用

U-99194 is a putative D3 antagonist with a 30-fold preference for the dopamine D3 vs. D2 receptor.

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

U-99194 maleate salt is soluble in water at a concentration >5 mg/ml.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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T Kling-Petersen et al.
Journal of neural transmission. General section, 102(3), 209-220 (1995-01-01)
Compounds showing an in vitro binding preference for the dopamine D3 vs. D2 receptors were tested for effects on locomotor activity after local application in the nucleus accumbens (N Acc) and the ventral tegmental area (VTA) of the rat brain.
Jose R Eguibar et al.
Neuroscience letters, 483(3), 189-192 (2010-08-10)
The taiep rat is a myelin mutant whose immobility episodes (IEs) can be caused by gripping them by the tail. Electroencephalographic recordings during IEs show a rapid-eye movement sleep-like pattern, similar to narcolepsy-cataplexy in canines. Systemic administration of alpha(2)-adrenoceptor agonists
Jose R Eguibar et al.
Pharmacology, biochemistry, and behavior, 102(1), 118-123 (2012-04-14)
Systemic administration of D2-like dopaminergic-receptor agonists increases yawning behavior. However, only a few studies have been done in animals with pathological conditions. The taiep rat is a myelin mutant with an initial hypomyelination followed by progressive demyelination, being the brainstem
N Waters et al.
Journal of neural transmission. General section, 94(1), 11-19 (1993-01-01)
We report on the pharmacological effects of the 20 fold D3 vs. D2 dopamine receptor preferring compound U99194A. It is shown that U99194A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the

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