U1752
尿苷5-单磷酸
≥98%, natural (organic), powder
别名:
U 5′-P, UMP, 尿苷酸
产品名称
尿苷5-单磷酸, ≥98%
生物来源
natural (organic)
质量水平
方案
≥98%
表单
powder
溶解性
H2O: soluble 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
OC1C(O)C(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
InChI
1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)
InChI key
DJJCXFVJDGTHFX-UHFFFAOYSA-N
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一般描述
尿苷5′-单磷酸盐可用作所有嘧啶核苷酸的前体。
应用
5′-尿苷单磷酸可作为等渗溶液伤口屏障重建实验中E3等渗液的组分，研究其对等渗液中基底细胞反应或上皮细胞向伤口迁移的影响。
生化/生理作用
5′-尿苷单磷酸(UMP)是RNA中的一种核苷酸单体，由核碱基尿嘧啶、核糖和磷酸组成。UMP作为膳食补充剂可增强神经递质释放和神经突生长，也可促进成年大鼠膜磷脂的生产。对成年沙鼠联合喂饲DHA和UMP后，树突棘和神经元膜合成增加。表明UMP可用于突触缺失引起的认知障碍治疗。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Regulation of uridylic acid biosynthesis in the cyanobacterium Anabaena variabilis.
Currier TC and Wolk CP
Journal of Bacteriology, 136(2), 682-687 (1978)
Lei Wang et al.
Journal of molecular neuroscience : MN, 27(1), 137-145 (2005-08-02)
Membrane phospholipids like phosphatidylcholine (PC) are required for cellular growth and repair, and specifically for synaptic function. PC synthesis is controlled by cellular levels of its precursor, cytidine-5'-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. In
Xiaozhen Chen et al.
Journal of pharmaceutical and biomedical analysis, 174, 432-440 (2019-06-21)
A novel, simple, and efficacious analytical method for determining of nucleotides in Anoectochilus roxburghii (Wall.) Lindl (A. roxburghii) was developed. Magnetic dispersive solid-phase micro-extraction (MDSPME) combined with high-performance liquid chromatography was applied for extraction and determination of three nucleotides, such
Toshimasa Sakamoto et al.
Brain research, 1182, 50-59 (2007-10-24)
Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while
Chaitanya V Mungi et al.
Life (Basel, Switzerland), 9(3) (2019-07-07)
Polymerization of nucleotides under prebiotically plausible conditions has been a focus of several origins of life studies. Non-activated nucleotides have been shown to undergo polymerization under geothermal conditions when subjected to dry-wet cycles. They do so by a mechanism similar
实验方案
ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.
HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.
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