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Merck
CN

U1752

Sigma-Aldrich

尿苷5-单磷酸

≥98%

别名:

U 5′-P, UMP, 尿苷酸

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About This Item

经验公式(希尔记法):
C9H13N2O9P
CAS号:
分子量:
324.18
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51

生物来源

natural (organic)

质量水平

检测方案

≥98%

形式

powder

溶解性

H2O: soluble 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

OC1C(O)C(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O

InChI

1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)

InChI key

DJJCXFVJDGTHFX-UHFFFAOYSA-N

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一般描述

尿苷5′-单磷酸盐可用作所有嘧啶核苷酸的前体。

应用

5′-尿苷单磷酸可作为等渗溶液伤口屏障重建实验中E3等渗液的组分,研究其对等渗液中基底细胞反应或上皮细胞向伤口迁移的影响。

生化/生理作用

5′-尿苷单磷酸(UMP)是RNA中的一种核苷酸单体,由核碱基尿嘧啶、核糖和磷酸组成。UMP作为膳食补充剂可增强神经递质释放和神经突生长,也可促进成年大鼠膜磷脂的生产。对成年沙鼠联合喂饲DHA和UMP后,树突棘和神经元膜合成增加。表明UMP可用于突触缺失引起的认知障碍治疗。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Regulation of uridylic acid biosynthesis in the cyanobacterium Anabaena variabilis.
Currier TC and Wolk CP
Journal of Bacteriology, 136(2), 682-687 (1978)
Lei Wang et al.
Journal of molecular neuroscience : MN, 27(1), 137-145 (2005-08-02)
Membrane phospholipids like phosphatidylcholine (PC) are required for cellular growth and repair, and specifically for synaptic function. PC synthesis is controlled by cellular levels of its precursor, cytidine-5'-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. In
Toshimasa Sakamoto et al.
Brain research, 1182, 50-59 (2007-10-24)
Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while
Xiaozhen Chen et al.
Journal of pharmaceutical and biomedical analysis, 174, 432-440 (2019-06-21)
A novel, simple, and efficacious analytical method for determining of nucleotides in Anoectochilus roxburghii (Wall.) Lindl (A. roxburghii) was developed. Magnetic dispersive solid-phase micro-extraction (MDSPME) combined with high-performance liquid chromatography was applied for extraction and determination of three nucleotides, such
Masahiro Fujihashi et al.
The Journal of biological chemistry, 288(13), 9011-9016 (2013-02-12)
Orotidine 5'-monophosphate decarboxylase (ODCase) accelerates the decarboxylation of its substrate by 17 orders of magnitude. One argument brought forward against steric/electrostatic repulsion causing substrate distortion at the carboxylate substituent as part of the catalysis has been the weak binding affinity

实验方案

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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