U3385
UA62784
≥98% (HPLC)
别名:
4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
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关于此项目
经验公式（希尔记法）:
C23H15NO3
化学文摘社编号:
分子量:
353.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
产品名称
UA62784, ≥98% (HPLC)
Quality Level
color
yellow
solubility
DMSO: >2 mg/mL
storage temp.
2-8°C
InChI
1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
SMILES string
COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
InChI key
SVICLWPFAQYZLX-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
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Biochem/physiol Actions
Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
Preparation Note
UA62784 is soluble in DMSO at a concentration >2 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sergey Tcherniuk et al.
Chemistry & biology, 18(5), 631-641 (2011-05-26)
A recent screen for compounds that selectively targeted pancreatic cancer cells isolated UA62784. We found that UA62784 inhibits microtubule polymerization in vitro. UA62784 interacts with tubulin dimers ten times more potently than colchicine, vinblastine, or nocodazole. Competition experiments revealed that UA62784
Julia Würtemberger et al.
PloS one, 15(9), e0238572-e0238572 (2020-09-09)
Functional genomic screening of KRAS-driven mouse sarcomas was previously employed to identify proliferation-relevant genes. Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2), and CAMP Responsive Element Binding Protein 3 Like 2 (Creb3l2). This
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