U3385
UA62784
≥98% (HPLC)
别名:
4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one
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关于此项目
经验公式（希尔记法）:
C23H15NO3
化学文摘社编号:
分子量:
353.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: >2 mg/mL
storage temp.
2-8°C
SMILES string
COc1ccc(cc1)-c2cnc(o2)-c3cccc4C(=O)c5ccccc5-c34
InChI
1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
InChI key
SVICLWPFAQYZLX-UHFFFAOYSA-N
Biochem/physiol Actions
Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
Preparation Note
UA62784 is soluble in DMSO at a concentration >2 mg/ml.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable