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表单
lyophilized powder
分子量
heavy chain 30,400 Da
light chain 2000 Da
储存温度
2-8°C
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应用
人肾细胞产生的尿激酶已被用作消化混合物的成分，用于三维纤维蛋白培养。也用于纤溶酶原激活试验。
生化/生理作用
尿激酶可促进肾肿瘤细胞的增殖。
尿激酶是一种蛋白酶，能裂解纤溶酶原形成纤溶酶。与细胞表面受体 (uPAR) 结合，在组织重塑过程中调节细胞粘附和迁移，并激活细胞内信号通路。尿激酶由三个结构域组成：与表皮生长因子同源的氨基末端结构域通过中央圈形区结构域连接到羧基端的蛋白酶结构域。
物理属性
主要活性成分是尿激酶的低分子量形式，由 2,000 道尔顿的 A 链和 30,400 道尔顿的 B 链通过巯基键连接而成。
供应的冻干粉，含有人血白蛋白、甘露醇和 NaCl。
其他说明
注：当人纤维蛋白溶酶原作为底物时，活性更高。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The multifaceted roles of Leptospira enolase
Salazar N, et al.
Research in Microbiology, 168(2), 157-164 (2017)
Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin beta and fabricated fibrin matrices
Gavin KM, et al.
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J C Kirchheimer et al.
Carcinogenesis, 9(11), 2121-2123 (1988-11-01)
Primary cultures of renal cell carcinomas and of the corresponding normal adjacent kidney tissue from 6 patients were analyzed for the effects of exogenously added urokinase-type plasminogen activator on cell proliferation as compared to the effects of tissue type plasminogen
N Harbeck et al.
European journal of cancer (Oxford, England : 1990), 49(8), 1825-1835 (2013-03-16)
Final 10-year analysis of the prospective randomised Chemo-N0 trial is presented. Based on the Chemo-N0 interim results and an European Organisation for Research and Treatment of Cancer (EORTC) pooled analysis (n=8377), American Society of Clinical Oncology (ASCO) and Arbeitsgemeinschaft Gynäkologische
Banafsheh Afsharimani et al.
Clinical & experimental metastasis, 31(2), 149-158 (2013-09-28)
Opioids including morphine are commonly used in pain management during and after cancer surgery but have been linked to a variety of pro- and anti-tumor effects. In the present study the effect of morphine administration on the localization and growth
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