U5377
尿嘧啶1-β-D-阿拉伯呋喃糖苷
≥98% (HPLC), synthetic (organic), powder
别名:
Arauridine, Spongouridin, 1-β-D-阿拉伯呋喃糖尿嘧啶
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关于此项目
经验公式（希尔记法）:
C9H12N2O6
化学文摘社编号:
分子量:
244.20
Beilstein:
28749
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
尿嘧啶1-β-D-阿拉伯呋喃糖苷, lymphoma antiproliferative
生物来源
synthetic (organic)
质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1
InChI key
DRTQHJPVMGBUCF-CCXZUQQUSA-N
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一般描述
阿糖尿苷(1-β-d-arabinofuranosyluracil, Ara-U)是阿糖胞苷 (1-β-d-arabinofuranosylcytosin, Ara-C) 的解毒产物或代谢产物。阿糖尿苷(Uracil 1-β-D-arabinofuranoside）是一种名为阿糖胞苷 (CYT) 的细胞生长抑制剂的人体代谢物。
应用
阿糖尿苷(Uracil 1-β-D-arabinofuranoside）可用作通过亲水相互作用色谱/串联质谱法分析医院废水细胞抑制剂和代谢物含量的标准化合物，检验分析实验的可行性和局限性。它还可用作化学分析标准品，研究细胞毒性抗肿瘤药物的生态毒性和遗传毒性，如阿糖胞苷 (CYT) 及其代谢物（如阿糖尿苷(uracil-1-β-d-arabinofuranoside, AraU)）。
生化/生理作用
17 μM浓度的阿糖尿苷(1-β-D-Arabinofuranosyluracil, ara-U)能够抑制 L5178Y 小鼠淋巴瘤细胞增殖。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells.
W E Müller et al.
Cancer research, 39(3), 1102-1107 (1979-03-01)
Radka Zounkova et al.
Chemosphere, 81(2), 253-260 (2010-07-14)
In spite of growing scientific concern about pharmaceuticals in the environment, there is still a lack of information especially with regard to their metabolites. The present study investigated ecotoxicity and genotoxicity of three widely used cytostatic agents 5-fluorouracil (5-FU), cytarabine
Lubomira Kovalova et al.
Journal of chromatography. A, 1216(7), 1100-1108 (2009-01-13)
A method for solid phase extraction and HPLC-MS/MS of the cytostatics 5-fluorouracil, cytarabine, and gemcitabine and human metabolites uracil 1-beta-d-arabinofuranoside and 2',2'-difluorodeoxyuridine in wastewater was established. Wastewater samples from a Swiss hospital were analyzed for 5-fluorouracil, gemcitabine and 2',2'-difluorodeoxyuridine. The
P Linssen et al.
Journal of chromatography, 223(2), 371-378 (1981-05-08)
A method is described for the determination of 1-beta-D-arabinofuranosylcytosine (Ara-C) and its metabolite 1-beta-D-arabinofuranosyluracil (Ara-U) in human plasma. After deproteinization of the plasma sample, separation is performed by reversed-phase liquid chromatography. For Ara-C concentrations exceeding 0.05 mg/l and for Ara-U
Melissa N McCracken et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(5), 1857-1862 (2013-01-16)
Positron emission tomography (PET) reporter genes allow noninvasive whole-body imaging of transplanted cells by detection with radiolabeled probes. We used a human deoxycytidine kinase containing three amino acid substitutions within the active site (hdCK3mut) as a reporter gene in combination
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