Merck
CN

U5377

Sigma-Aldrich

尿嘧啶1-β-D-阿拉伯呋喃糖苷

lymphoma antiproliferative

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别名:
Arauridine, Spongouridin, 1-β-D-阿拉伯呋喃糖尿嘧啶
Empirical Formula (Hill Notation):
C9H12N2O6
CAS号:
分子量:
244.20
Beilstein:
28749
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.51

生物来源

synthetic (organic)

质量水平

检测方案

≥98% (HPLC)

形式

powder

溶解性

water: 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES string

OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-CCXZUQQUSA-N

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此商品
PHR3260U1128T3766
Uracil suitable for cell culture, BioReagent

Sigma-Aldrich

U1128

尿嘧啶

assay

≥98% (HPLC)

assay

-

assay

≥99% (HPLC)

assay

≥99%

form

powder

form

-

form

powder

form

powder

solubility

water: 50 mg/mL, clear, colorless

solubility

-

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

0.5 M HCl: 20 mg/mL, clear, colorless

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

一般描述

阿糖尿苷(1-β-d-arabinofuranosyluracil, Ara-U)是阿糖胞苷 (1-β-d-arabinofuranosylcytosin, Ara-C) 的解毒产物或代谢产物。阿糖尿苷(Uracil 1-β-D-arabinofuranoside)是一种名为阿糖胞苷 (CYT) 的细胞生长抑制剂的人体代谢物。

应用

阿糖尿苷(Uracil 1-β-D-arabinofuranoside)可用作通过亲水相互作用色谱/串联质谱法分析医院废水细胞抑制剂和代谢物含量的标准化合物,检验分析实验的可行性和局限性。它还可用作化学分析标准品,研究细胞毒性抗肿瘤药物的生态毒性和遗传毒性,如阿糖胞苷 (CYT) 及其代谢物(如阿糖尿苷(uracil-1-β-d-arabinofuranoside, AraU))。

生化/生理作用

17 μM浓度的阿糖尿苷(1-β-D-Arabinofuranosyluracil, ara-U)能够抑制 L5178Y 小鼠淋巴瘤细胞增殖。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Slide 1 of 2

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Uracil ≥99.0%

Sigma-Aldrich

U0750

尿嘧啶

Methyl sulfoxide ≥99%, FG

Sigma-Aldrich

W387520

甲基亚砜

Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells.
W E Müller et al.
Cancer research, 39(3), 1102-1107 (1979-03-01)
P Linssen et al.
Journal of chromatography, 223(2), 371-378 (1981-05-08)
A method is described for the determination of 1-beta-D-arabinofuranosylcytosine (Ara-C) and its metabolite 1-beta-D-arabinofuranosyluracil (Ara-U) in human plasma. After deproteinization of the plasma sample, separation is performed by reversed-phase liquid chromatography. For Ara-C concentrations exceeding 0.05 mg/l and for Ara-U
Radka Zounkova et al.
Chemosphere, 81(2), 253-260 (2010-07-14)
In spite of growing scientific concern about pharmaceuticals in the environment, there is still a lack of information especially with regard to their metabolites. The present study investigated ecotoxicity and genotoxicity of three widely used cytostatic agents 5-fluorouracil (5-FU), cytarabine
Melissa N McCracken et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(5), 1857-1862 (2013-01-16)
Positron emission tomography (PET) reporter genes allow noninvasive whole-body imaging of transplanted cells by detection with radiolabeled probes. We used a human deoxycytidine kinase containing three amino acid substitutions within the active site (hdCK3mut) as a reporter gene in combination
Yoon-Ok Jang et al.
BMC gastroenterology, 12, 4-4 (2012-01-11)
Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been observed in patients with chronic HBV infection taking clevudine. Moreover, the development of

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