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Merck
CN

U5625

尿苷-5′-二磷酸葡糖醛酸 铵盐

98-100%, from Saccharomyces cerevisiae, powder

别名:

UDP-GlcA, UDPGA, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid 铵盐, 尿苷-二磷酸-葡萄糖醛酸 铵盐

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关于此项目

经验公式(希尔记法):
C15H22N2O18P2 · xNH3
化学文摘社编号:
分子量:
580.29 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
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产品名称

尿苷-5′-二磷酸葡糖醛酸 铵盐, 98-100%

SMILES string

N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1

InChI key

WMWKTCPGFOEPBD-YGIWDPDDSA-N

biological source

Saccharomyces cerevisiae
enzyme from bovine liver (catalase)
enzyme from rabbit muscle (LDH)

assay

98-100%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

Application

尿苷 5'-二磷酸葡萄糖醛酸铵盐已用于肝 S9 蛋白中 14 C-睾酮的 UDP-葡糖醛酸基转移酶 (UDGPT) 试验的启动。适用于 UDGPT 含量测定。

Biochem/physiol Actions

尿苷 5'-二磷酸葡萄糖醛酸 (UDGPA) 是内质网中胆红素结合的葡萄糖醛酸供体。

General description

尿苷 5′-二磷酸葡萄糖醛酸 (UDPGA) 是辅助因子,由 udp-葡萄糖和烟酰胺腺嘌呤二核苷酸 (NAD +) 在细胞内通过 udp-葡萄糖脱氢酶的催化活性合成。许多肝制备液中 UDPGA 的浓度范围为 0.3-0.5 mM。

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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分析证书(COA)

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Walker's Pediatric Gastrointestinal Disease, 768-768 (2008)
Shupeng Yang et al.
Journal of agricultural and food chemistry, 65(51), 11292-11303 (2017-12-06)
To explore differences of zearalenone (ZEN) metabolism between various species, phase I and II metabolism by liver microsomes of animals and human were investigated using ultra high-pressure liquid chromatography-quadrupole/time-of-flight mass spectrometry (UHPLC-Q/TOF MS). A total of 24 metabolites were identified
Ankit Parikh et al.
International journal of pharmaceutics, 515(1-2), 490-500 (2016-11-05)
Edaravone (EDR), a strong free radical scavenger, is known for its promising therapeutic potential in oxidative stress (OS) associated diseases, however poor oral bioavailability is the major obstacle in its potential use. Oral liquid dosage form is the most preferred
Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels
Kuriyama SN, et al.
Toxicology, 242(1-3), 80-90 (2007)
Malgorzata Szultka-Mlynska et al.
Analytical and bioanalytical chemistry, 408(29), 8273-8287 (2016-10-25)
High performance liquid chromatography coupled with triple-quadrupole mass spectrometry was applied in the determination of in vitro metabolism products of selected antibiotic drugs (cefotaxime, ciprofloxacin, fluconazole, gentamicin, clindamycin, linezolid, and metronidazole). The analytes were separated on a reversed phase C18

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