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Merck
CN

U5754

Urodilatin human

≥97% (HPLC)

别名:

Thr-Ala-Pro-Arg-Atrial Natriuretic Peptide

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关于此项目

经验公式（希尔记法）:
C145H234N52O44S3
化学文摘社编号:
115966-23-9
分子量:
3505.93
NACRES:
NA.32
PubChem Substance ID:
329827637
UNSPSC Code:
12352200
MDL number:
MFCD00076227
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
human

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InChI

1S/C145H234N52O44S3/c1-11-72(6)112-137(238)171-60-106(208)172-73(7)113(214)177-86(40-41-103(146)205)122(223)190-95(63-198)116(217)170-61-108(210)175-88(51-70(2)3)114(215)169-62-109(211)176-100(133(234)187-92(56-104(147)206)127(228)193-97(65-200)130(231)186-91(54-77-27-16-13-17-28-77)126(227)180-82(31-20-45-163-142(153)154)119(220)189-94(139(240)241)55-78-36-38-79(204)39-37-78)68-243-244-69-101(134(235)185-90(53-76-25-14-12-15-26-76)115(216)168-58-105(207)167-59-107(209)174-80(29-18-43-161-140(149)150)117(218)182-87(42-50-242-10)123(224)188-93(57-110(212)213)128(229)181-85(124(225)196-112)34-23-48-166-145(159)160)195-132(233)99(67-202)194-131(232)98(66-201)192-120(221)83(32-21-46-164-143(155)156)178-118(219)81(30-19-44-162-141(151)152)179-125(226)89(52-71(4)5)184-129(230)96(64-199)191-121(222)84(33-22-47-165-144(157)158)183-135(236)102-35-24-49-197(102)138(239)74(8)173-136(237)111(148)75(9)203/h12-17,25-28,36-39,70-75,80-102,111-112,198-204H,11,18-24,29-35,40-69,148H2,1-10H3,(H2,146,205)(H2,147,206)(H,167,207)(H,168,216)(H,169,215)(H,170,217)(H,171,238)(H,172,208)(H,173,237)(H,174,209)(H,175,210)(H,176,211)(H,177,214)(H,178,219)(H,179,226)(H,180,227)(H,181,229)(H,182,218)(H,183,236)(H,184,230)(H,185,235)(H,186,231)(H,187,234)(H,188,224)(H,189,220)(H,190,223)(H,191,222)(H,192,221)(H,193,228)(H,194,232)(H,195,233)(H,196,225)(H,212,213)(H,240,241)(H4,149,150,161)(H4,151,152,162)(H4,153,154,163)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166)/t72-,73-,74-,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-/m0/s1

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccc(O)cc4)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]5CCCN5C(=O)[C@H](C)NC(=O)[C@@H](N)[C@@H](C)O

InChI key

IUCCYQIEZNQWRS-DWWHXVEHSA-N

biological source

human

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ~70%

technique(s)

activity assay: suitable

UniProt accession no.

P01160

storage temp.

−20°C

Quality Level

200

Gene Information

human ... NPPA(4878)

Application

Human Urodilatin can be used as a test compound for examining the activity and mechanisms of action of urodilatin in bovine bronchi. It used to investigate the effect on bronchodilatation and protect against subsequent challenge with alpha-human atrial natriuretic peptide (ANP).

Biochem/physiol Actions

Urodilatin is a natriuretic factor belongs to atrial natriuretic peptide family which along with four cardiac hormones decreases human renal carcinoma cell numbers. Urodilatin induces cGMP synthesis as well as stimulates cGMP accumulation by threefold in inner medullary collecting ducts (IMCD).
Urodilatin is a natriuretic factor that is produced in the kidney and secreted into the urine. It regulates water and sodium reabsorption in the collecting duct.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000481300
0000481300
0000459863
0000459863
0000457030

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J Koike et al.
Journal of the American Society of Nephrology : JASN, 3(10), 1705-1709 (1993-04-01)
Urodilatin is found in the urine and is thought to be produced in the kidney. The effect of urodilatin on cGMP accumulation in the kidney was investigated. cGMP accumulation by urodilatin and atrial natriuretic peptide (ANP) were compared with tubule
B A Vesely et al.
European journal of clinical investigation, 36(11), 810-819 (2006-10-13)
Mortality from renal-cell cancer remains a significant problem with an estimated 12,600 deaths in the United States in 2005 even with current treatment(s) of surgery, chemotherapy, radiation and immunotherapy. Four cardiac natriuretic peptides, that is, atrial natriuretic peptide, vessel dilator
W G Forssmann et al.
Histochemistry and cell biology, 110(4), 335-357 (1998-10-29)
This review focuses on some selected aspects of the endocrine heart and natriuretic peptides. The endocrine heart is composed of specific myoendocrine cells of the cardiac atria. The myoendocrine cells synthesize and secrete the natriuretic peptide hormones which exhibit natriuretic
M Heringlake et al.
The American journal of physiology, 277(3 Pt 2), F347-F351 (1999-09-14)
The findings about mechanisms regulating production and excretion of urodilatin [ANP-(95-126)], a member of the atrial natriuretic peptide (ANP) family, are controversial. To elucidate a possible relationship between arterial blood pressure and renal urodilatin excretion, we studied the effects of
C Bailly
Kidney international. Supplement, 65, S29-S35 (1998-04-29)
The thick ascending limb of Henle's loop (TAL) is involved in the urinary dilution/concentration process by actively reabsorbing NaCl through a complex mechanism. Some years ago, compelling evidence was provided that cAMP stimulates NaCl reabsorption through the activation of adenylyl
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