U8008
Anti-ULK2 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Ulk2 Antibody, Ulk2 Antibody - Anti-ULK2 antibody produced in rabbit, Anti-Unc-51 like kinase 2, Anti-Unc51.2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
9
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~130 kDa
species reactivity
mouse
concentration
~1.0 mg/mL
technique(s)
western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells expressing mouse ULK2
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ULK2(9706)
mouse ... Ulk2(29869)
rat ... Ulk2(303206)
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General description
Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) is encoded by the gene mapped to mouse chromosome 11. Mouse ULK2 (mULK2) belongs to the UNC-51-like protein kinase family. mULK2 protein is characterized with an amino-terminal kinase domain, a central proline/serine rich (PS) domain and a carboxy-terminal (C) domain. ULK2 is ubiquitously expressed and is mainly localized to autophagosomal membranes in mammalian cells.
Application
Anti-ULK2 antibody produced in rabbit has been used in western blot analysis and immunohistochemistry.
Biochem/physiol Actions
Uncoordinated family member (unc)-51 like autophagy activating kinase 2 (ULK2) plays a crucial role in autophagy. It is also implicated in the regulation of elemental biological processes conserved among wide variety of species. Downregulated expression of the gene increases astrocyte transformation and tumor growth.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
Nazio F
Nature Cell Biology, 15, 406-416 (2013)
The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
Lee EJ and Tournier C
Autophagy, 7, 689-695 (2011)
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases.
Cheong H
Proceedings of the National Academy of Sciences of the USA, 108, 11121-11126 (2011)
Methylation Silencing of ULK2, an Autophagy Gene, Is Essential for Astrocyte Transformation and Tumor Growth
Shukla S
The Journal of Biological Chemistry, 289, 22306-22318 (2014)
Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse
Bi W
Genome Research, 12, 713-728 (2002)
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