Name: UCL 1684 ditrifluoroacetate hydrate
Brand: SIGMA

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About This Item

线性分子式:

(C₃₄H₃₀N₄)²⁺ · (C₂F₃O₂^-)₂ · xH₂O

CAS Number:

201147-19-5

分子量:

720.66 (anhydrous basis)

UNSPSC代码:

12352200

PubChem化学物质编号:

24900684

NACRES:

NA.77

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颜色

white to off-white

溶解性

DMSO: 10 mg/mL

SMILES字符串

[H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7

InChI

1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;

InChI key

YROHEYZVNZITJN-DDVHGCDCSA-N

应用

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries.

生化/生理作用

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca²⁺-activated K⁺channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.