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UC126

4-羟基美芬妥英

Name: 4-羟基美芬妥英
Brand: SIGMA

Cytochrome P450 inhibitor, solid

别名:

(±)-5-乙基-5-(4-羟苯基)-3-甲基海因, (±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₄N₂O₃

化学文摘社编号:

61837-65-8

分子量:

234.25

UNSPSC Code:

12161501

PubChem Substance ID:

24724640

NACRES:

NA.77

MDL number:

MFCD00142316

Form:

solid

Quality level:

200

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产品名称

4-羟基美芬妥英,

form

solid

Quality Level

200

color

white

mp

153-154 °C

storage temp.

2-8°C

SMILES string

CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2

InChI

1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)

InChI key

OQPLORUDZLXXPD-UHFFFAOYSA-N

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General description

美芬妥英的 YP2C19 代谢物。

Application

4-羟基苯乙妥英已被用于开发超高效液相色谱（UPLC）-串联质谱分析（MS/MS），以评估人尿或血浆样品中的细胞色素P450（CYP）探针药物及其相关代谢产物。4-羟基苯乙妥英还被用于开发一类基于亚2微米颗粒LC/MS/MS的方法来分析CYP450探针底物代谢产物。

Biochem/physiol Actions

4-羟基苯乙妥英分解代谢显示出了遗传多态性，并是细胞色素P450 2C19（CYP2C19）活性的一种直接指示剂。通过高效液相色谱对生物样品中4-羟基苯乙妥英的检测和定量已被充分的优化。

Packaging

无底玻璃瓶。内含物在插入的融合锥体内。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test

Tanaka M, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 87-94 (1996)

A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution.

Nicolas A Stewart et al.

The Analyst, 136(3), 605-612 (2010-11-26)

The efficiency of drug metabolism by a single enzyme can be measured as the fractional metabolic clearance which can be used as a measure of whole body activity for that enzyme. Measurement of activity of multiple enzymes simultaneously is feasible

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.

J K Coller et al.

British journal of clinical pharmacology, 48(2), 158-167 (1999-07-27)

To compare the oxidative metabolism of (S)-mephenytoin and proguanil in vitro and to determine the involvement of various cytochrome P450 isoforms. The kinetics of the formation of 4'-hydroxymephenytoin and cycloguanil in human liver microsomes from 10 liver samples were determined

High-performance liquid chromatographic determination of urinary 4'-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans.

H G Xie et al.

Journal of chromatography. B, Biomedical applications, 668(1), 125-131 (1995-06-09)

The preferential hydroxylation of (S)-mephenytoin to 4'-hydroxymephenytoin (4'-OH-M) displays a genetic polymorphism of drug metabolism in humans. Thus the excreted 4'-OH-M is considered to be an important marker for the hepatic (S)-mephenytoin 4'-hydroxylase. Accordingly, a mixture of urine containing total

Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.

A Adedoyin et al.

Clinical pharmacology and therapeutics, 64(1), 8-17 (1998-08-08)

Drug metabolism is influenced by liver disease because of the central role that the liver plays in metabolic activities in the body. However, it is still unclear how activities of specific drug-metabolizing enzymes are influenced by the presence and severity

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全球贸易项目编号

货号	GTIN
UC126-5MG	04061832931630
UC126-10MG	04061832931623

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