UC126
4-羟基美芬妥英
Cytochrome P450 inhibitor, solid
别名:
(±)-5-乙基-5-(4-羟苯基)-3-甲基海因, (±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮
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关于此项目
经验公式（希尔记法）:
C12H14N2O3
化学文摘社编号:
分子量:
234.25
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
产品名称
4-羟基美芬妥英,
表单
solid
质量水平
颜色
white
mp
153-154 °C
储存温度
2-8°C
SMILES字符串
CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2
InChI
1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)
InChI key
OQPLORUDZLXXPD-UHFFFAOYSA-N
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一般描述
美芬妥英的 YP2C19 代谢物。
应用
4-羟基苯乙妥英已被用于开发超高效液相色谱（UPLC）-串联质谱分析（MS/MS），以评估人尿或血浆样品中的细胞色素P450（CYP）探针药物及其相关代谢产物。4-羟基苯乙妥英还被用于开发一类基于亚2微米颗粒LC/MS/MS的方法来分析CYP450探针底物代谢产物。
生化/生理作用
4-羟基苯乙妥英分解代谢显示出了遗传多态性，并是细胞色素P450 2C19（CYP2C19）活性的一种直接指示剂。通过高效液相色谱对生物样品中4-羟基苯乙妥英的检测和定量已被充分的优化。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Paul D Rainville et al.
Rapid communications in mass spectrometry : RCM, 22(9), 1345-1350 (2008-04-03)
The measurement of cytochrome P450 (CYP450) isoenzyme inhibition is often done during evaluation of new chemical entities in drug discovery. Typical assay protocol consists of multiple CYP450 probe substrates incubated with selected drug candidates and CYP450. Results of the assay
Nicolas A Stewart et al.
The Analyst, 136(3), 605-612 (2010-11-26)
The efficiency of drug metabolism by a single enzyme can be measured as the fractional metabolic clearance which can be used as a measure of whole body activity for that enzyme. Measurement of activity of multiple enzymes simultaneously is feasible
Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test
Tanaka M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 87-94 (1996)
High-performance liquid chromatographic determination of urinary 4?-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans
Xie HG, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 668(1), 125-131 (1995)
Reginald F Frye et al.
Clinical pharmacology and therapeutics, 80(3), 235-245 (2006-09-06)
The liver plays a significant role in drug metabolism; thus it would be expected that liver disease may have a detrimental effect on the activity of cytochrome P450 (CYP) enzymes. The extent to which the presence and severity of liver
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