UC148
6-羟基氯唑沙宗
≥98% (HPLC), solid, chlorzoxazone metabolite
别名:
5-Chloro-6-hydroxybenzoxazone, 5-氯-6-羟基-2(3H)-苯并噁唑酮
产品名称
6-羟基氯唑沙宗, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white to pink
溶解性
methanol: soluble
储存温度
2-8°C
SMILES字符串
Oc1cc2OC(=O)Nc2cc1Cl
InChI
1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)
InChI key
AGLXDWOTVQZHIQ-UHFFFAOYSA-N
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应用
6-羟基氯唑沙宗已用于基于 HPLC 的氯唑沙宗代谢分析 。
6-羟基氯唑沙宗已被用作：作为参考标准品，在重组人酶筛选中监测底物消耗或通过细胞色素 P450 家族 2 亚家族 E 成员 1 (CYP2E1) 所形成的 6-羟基氯唑沙宗。6-羟基氯唑沙宗已被用于基于高效液相色谱 (HPLC) 的氯唑沙宗代谢测定。
氯唑沙宗的 CYP2E1 & 1A2 代谢物。
生化/生理作用
6-羟基氯唑沙宗是一种新型氯唑沙宗代谢物。它是由细胞色素 P450 家族 2 亚家族 E 成员 1 (CYP2E1) 酶将氯唑沙宗羟基化形成的。确定 6-羟基氯唑沙宗的形成和清除被用作表征 CYP2E1 代谢活性的一种可靠标记。
包装
无底玻璃瓶。内含物装在插入的融合锥内。
制备说明
6-羟基氯唑沙宗可溶于甲醇。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
In vitro CYP/FMO Reaction Phenotyping
Optimization in Drug Discovery: In Vitro Methods, 137-169 (2014)
Drug Metabolism in Chronic Kidney Disease
Chronic Renal Disease, 1035-1051 (2020)
C B Eap et al.
Journal of chromatography. B, Biomedical sciences and applications, 705(1), 139-144 (1998-03-14)
A gas chromatographic-mass spectrometric method is presented which allows the determination of chlorzoxazone and 6-hydroxychlorzoxazone after derivatization with the reagent N-tert.-butyldimethylsilyl-N-methyltrifluoroacetamide. No interference was observed from endogenous compounds following the extraction of plasma samples from six different human subjects. The
Young Jin Moon et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(6), 776-784 (2003-05-21)
The purpose of this study is to report the changes of CYP2E1, CYP1A2, CYP2B1/2, CYP2C11, CYP3A23, and CYP3A2 expression and pharmacokinetics and tissue distribution of chlorzoxazone (CZX) and 6-hydroxychlorzoxazone (OH-CZX) in rats with acute renal failure induced by uranyl nitrate
Hye W Baek et al.
Journal of pharmaceutical sciences, 95(11), 2452-2462 (2006-08-04)
Pharmacokinetic parameters of chlorzoxazone (CZX) and its main metabolite, 6-hydroxychlorzoxazone (OH-CZX), were compared after intravenous (20 mg/kg) and oral (50 mg/kg) administration of CZX in rat model of diabetes induced by alloxan (DMIA) or streptozotocin (DMIS), and their respective control
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