UC160
4-羟基甲苯磺丁脲
≥98% (HPLC)
别名:
N-(丁基氨基甲酰)-4-羟甲基苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C12H18N2O4S
化学文摘社编号:
分子量:
286.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
assay
≥98% (HPLC)
form
solid
color
white
mp
100-102 °C
solubility
ethanol: soluble 12 mg/mL, 0.1 M NaOH: soluble 4 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1
InChI
1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
InChI key
SJRHYONYKZIRPM-UHFFFAOYSA-N
Application
4-羟基甲苯磺丁脲已用作标准品，用于测定从甲苯磺丁脲到4'-羟基甲苯磺丁脲的真菌生物转化。
Packaging
无底玻璃瓶。内含物装在插入式熔锥内。
Preparation Note
4-羟基甲苯磺丁脲可溶于乙醇（浓度为 12 mg/mL），也可溶于 0.1 MNaOH（浓度为 4 mg/mL）。它不溶于水。
Other Notes
甲苯磺丁脲的代谢物；通过 P450 酶的细胞色素 CYP2CIIC8 和 IIC9 亚家族形成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.
J O Miners et al.
Methods in enzymology, 272, 139-145 (1996-01-01)
Julia Kirchheiner et al.
Pharmacogenetics, 12(2), 101-109 (2002-03-05)
Tolbutamide is known to be metabolized by cytochrome P450 2C9 (CYP2C9), and the effects of the CYP2C9 amino acid polymorphisms *2 (Arg144Cys) and *3 (Ile359Leu) could be important for drug treatment with tolbutamide and for use of tolbutamide as a
Ji-Hong Shon et al.
Pharmacogenetics, 12(2), 111-119 (2002-03-05)
Several recent in-vitro data have revealed that CYP2C19, in addition to CYP2C9, is also involved in the 4-methylhydroxylation of tolbutamide. We evaluated the relative contribution of CYP2C9 and CYP2C19 genetic polymorphisms on the disposition of blood glucose lowering response to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| UC160-10MG | 04061837410161 |
| UC160-5MG | 04061837410178 |