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Merck
CN

UC166

磺胺苯吡唑

≥98% (HPLC)

别名:

4-氨基-N-(1-苯基-1H-吡唑-5-基)苯磺酰胺

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关于此项目

经验公式(希尔记法):
C15H14N4O2S
化学文摘社编号:
分子量:
314.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
208-384-3
MDL number:
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InChI

1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2

InChI key

QWCJHSGMANYXCW-UHFFFAOYSA-N

SMILES string

Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3

assay

≥98% (HPLC)

form

solid

color

white to light yellow

mp

179-183 °C

storage temp.

2-8°C

Gene Information

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Biochem/physiol Actions

抗细菌。CYP2C9的特异性抑制剂。阻断由CYP2C9介导的亚油酸(氧化应激和AP-1活化增加)的促炎症和致动脉粥样硬化作用。CYP2C9的特异性抑制剂。阻断由CYP2C9介导的亚油酸(氧化应激和AP-1活化增加)的促炎症和致动脉粥样硬化作用。抑制缓激肽诱导的tPA释放。

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mahmood Khan et al.
Antioxidants & redox signaling, 11(4), 725-738 (2008-10-16)
The objective of this study was to establish the cardioprotective effect of sulfaphenazole (SPZ), a selective inhibitor of cytochrome P450 2C9 enzyme, in an in vivo rat model of acute myocardial infarction (MI). MI was induced by 30 min ligation
Vienna E Brunt et al.
The Journal of physiology, 590(15), 3523-3534 (2012-06-08)
While it is accepted that NO is responsible for ∼60% of the plateau in cutaneous thermal hyperaemia, a large portion of the response remains unknown. We sought to determine whether the remaining ∼40% could be attributed to EDHF-mediated activation of
Chengqun Huang et al.
American journal of physiology. Heart and circulatory physiology, 298(2), H570-H579 (2009-12-17)
Previously, we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against ischemia-reperfusion (I/R) injury (Ref. 15). The mechanism, however, underlying this cardioprotection, is largely unknown. With evidence that activation of autophagy
Agostino Virdis et al.
The Journal of clinical endocrinology and metabolism, 95(2), 920-927 (2009-12-22)
The aim of this study was to assess whether patients with primary hyperparathyroidism (PHPT) show reduced endothelial function and to determine the mechanisms involved. The impact of parathyroidectomy (PTx) on endothelial function was also assessed. Endothelial dysfunction is reported in
Shu-Ying Chang et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2513-2522 (2008-09-13)
Various groups have sought to determine the impact of CYP2C8 genotype (and CYP2C8 inhibition) on the pharmacokinetics (PK) of ibuprofen (IBU) enantiomers. However, the contribution of cytochrome P450 2C8 (CYP2C8) in human liver microsomes (HLMs) has not been reported. Therefore

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