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UC167

Oxidized Nifedipine

Name: Oxidized Nifedipine
Brand: SIGMA

powder, ~95% (HPLC)

别名:

2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₆N₂O₆

化学文摘社编号:

67035-22-7

分子量:

344.32

NACRES:

NA.77

PubChem Substance ID:

329827652

UNSPSC Code:

12161501

MDL number:

MFCD00153847

Assay:

~95% (HPLC)

Form:

powder

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属性

assay

~95% (HPLC)

Quality Segment

200

form

powder

color

yellow

mp

100-105 °C

storage temp.

2-8°C

SMILES string

COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O

InChI

1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3

InChI key

UMQHJQGNGLQJPF-UHFFFAOYSA-N

说明

Application

Oxidized Nifedipine may be used:

to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS05

signalword

Danger

hcodes

H318

pcodes

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000281414

0000099636

0000232143