Oxidized Nifedipine

Name: Oxidized Nifedipine
Brand: SIGMA

powder, ~95% (HPLC)

别名:

2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₇H₁₆N₂O₆

CAS Number:

67035-22-7

分子量:

344.32

MDL编号:

MFCD00153847

UNSPSC代码:

12161501

PubChem化学物质编号:

329827652

NACRES:

NA.77

方案

~95% (HPLC)

表单

powder

颜色

yellow

mp

100-105 °C

储存温度

2-8°C

SMILES字符串

COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O

InChI

1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3

InChI key

UMQHJQGNGLQJPF-UHFFFAOYSA-N

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应用

Oxidized Nifedipine may be used:

to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes
in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons.

生化/生理作用

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Nifedipine is a dihydropyridine derivative and a calcium channel blocker. It is used in treating hypertension and angina pectoris. Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light. The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.