UC168
(±)-Bufuralol hydrochloride
≥98% (HPLC), solid, β-Adrenoceptor agonist/antagonist
别名:
α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H23NO2·HCl
化学文摘社编号:
分子量:
297.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
262-216-3
MDL number:
Form:
solid
Quality level:
产品名称
(±)-Bufuralol hydrochloride,
form
solid
Quality Level
color
white to off-white
mp
143-146 °C
solubility
H2O: soluble, methanol: soluble
storage temp.
2-8°C
SMILES string
Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C
InChI
1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H
InChI key
KJBONRGCLLBWCJ-UHFFFAOYSA-N
Application
CYP2D6 substrate
Biochem/physiol Actions
β-Blocker. Varying β-adrenoceptor agonist/antagonist activity.
Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
(±)-Bufuralol hydrochloride is soluble in water and methanol.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
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商品
Discover Bioactive Small Molecules for ADME/Tox
Kazuhide Iwasaki et al.
Drug metabolism and pharmacokinetics, 25(4), 388-391 (2010-09-04)
Drug metabolizing activities of cytochromes P450 (P450s, or CYPs) 3A4 and 3A5 in liver microsomes from the cynomolgus monkey [Macaca fascicularis (mf)] were investigated and compared with those of human P450 3A enzymes. Low activities for dealkylation of ethoxyresorufin and
D Magometschnigg et al.
International journal of clinical pharmacology and biopharmacy, 17(11), 429-432 (1979-11-01)
In this hemodynamic study a new beta-receptor blocker, Bufuralol-hydrochloride was compared with Pindolol under an Isoproterenol infusion with increasing doses in healthy male volunteers. We found the following results: 1. Before Isoproterenol peripheral resistance increased after acute i.v. application of
Jialin Mao et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(4), 706-716 (2012-01-10)
Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal of this study was to compare the accuracy of DDI
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| UC168-10MG | 04061832931746 |
| UC168-5MG | 04061837410185 |