UC205
右旋糖酐
NMDA glutamate receptor antagonist, solid
别名:
(+)-3-Hydroxy-17-methylmorphinan, 1,3,4,9,10,10a-Hexahydro-6-hydroxy-2H-10,4a-(iminoethano)-11-methylphenanthrene
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选择尺寸
关于此项目
经验公式（希尔记法）:
C17H23NO
化学文摘社编号:
分子量:
257.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
204-754-3
MDL number:
产品名称
右旋糖酐,
InChI key
JAQUASYNZVUNQP-PVAVHDDUSA-N
InChI
1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1
SMILES string
CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34
form
solid
optical activity
[α]/D ≥+54°
color
white to off-white
mp
≥195 °C
solubility
saline: soluble(lit.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... GRIN2A(2903)
rat ... Grin2a(24409)
Application
CYP2D6 O-Demethyl metabolite of dextromethorphan
Dextrorphan has been studies as an N-methyl-D-aspartate (NMDA) receptor antagonist in Xenopus oocytes and hippocampal neuron cultures.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
Dextrorphan is soluble in water.
Ihab R Kamel et al.
Journal of neurosurgical anesthesiology, 20(4), 241-248 (2008-09-25)
Ketamine, an intravenous anesthetic and a major drug of abuse, is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Ketamine's enantiomer, S(+)-ketamine, acts stereoselectively on neuronal NMDA receptors. The purpose of this in vitro study was to compare the direct effects of
Chris G Parsons et al.
Methods in molecular biology (Clifton, N.J.), 403, 15-36 (2008-10-02)
Electrophysiological techniques can be used to great effect to help determine the mechanism of action of a compound. However, many factors can compromise the resulting data and their analysis, such as the speed of solution exchange, expression of additional ion
F Girardin et al.
Journal of viral hepatitis, 19(8), 568-573 (2012-07-06)
Liver kidney microsomal type 1 (LKM-1) antibodies have been shown to decrease the CYP2D6 activity in vitro and are present in a minority of patients with chronic hepatitis C infection. We investigated whether LKM-1 antibodies might reduce the CYP2D6 activity
XiaoMei Zhuang et al.
Biochemical pharmacology, 121, 67-77 (2016-09-27)
Icotinib (ICO), a novel small molecule and a tyrosine kinase inhibitor, was developed and approved recently in China for non-small cell lung cancer. During screening for CYP inhibition potential in human liver microsomes (HLM), heterotropic activation toward CYP3A5 was revealed.
Jaydeep Yadav et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(7), 732-742 (2019-05-03)
Nonspecific drug partitioning into microsomal membranes must be considered for in vitro-in vivo correlations. This work evaluated the effect of including lipid partitioning in the analysis of complex TDI kinetics with numerical methods. The covariance between lipid partitioning and multiple
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