UC214
(S)-(−)-华法林
≥97% (HPLC), CYP2C9 substrate, solid
别名:
S-(−)-3-Acetonybenzyl)-4-hydroxycoumarin, S-(−)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
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关于此项目
经验公式（希尔记法）:
C19H16O4
化学文摘社编号:
分子量:
308.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
EC Number:
226-907-3
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
产品名称
(S)-(−)-华法林, ≥97% (HPLC)
assay
≥97% (HPLC)
form
solid
color
white to pale yellow
mp
≥170 °C
storage temp.
2-8°C
SMILES string
[H][C@](CC(C)=O)(c1ccccc1)C2=C(O)c3ccccc3OC2=O
InChI
1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m0/s1
InChI key
PJVWKTKQMONHTI-HNNXBMFYSA-N
Gene Information
human ... CYP2C9(1559)
General description
Warfarin is an antagonist of vitamin K. It is an oral coumarin anticoagulant.
Application
(S)-(−)-Warfarin has been used in cell cultures.
Studies using (R)-(+)-warfarin have reported that it can upregulate hepatic CYP3A4 and CYP2C. It has also been used in HepG2 cells to study protein profiles.
Biochem/physiol Actions
Warfarin is used to regulate and inhibit thromboembolic disorders. The CYP2C9 (cytochrome P450 family 2 subfamily C member 9) protein plays a major role in the inactivation of potent S-warfarin.
CYP2C9 substrate; anticoagulant.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Repr. 1A - STOT RE 1
target_organs
Blood
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable