UC261
(±)-4-Hydroxydebrisoquin sulfate
别名:
(±)-2-Amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline sulfate, (±)-3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinecarboximidamide sulfate
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H13N3O · 0.5H2SO4
化学文摘社编号:
分子量:
240.27
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
质量水平
颜色
off-white
mp
267 °C
储存温度
2-8°C
SMILES字符串
OS(O)(=O)=O.NC(=N)N1CC(O)c2ccccc2C1.NC(=N)N3CC(O)c4ccccc4C3
InChI
1S/2C10H13N3O.H2O4S/c2*11-10(12)13-5-7-3-1-2-4-8(7)9(14)6-13;1-5(2,3)4/h2*1-4,9,14H,5-6H2,(H3,11,12);(H2,1,2,3,4)
InChI key
AETJLQVZNVTWPH-UHFFFAOYSA-N
相关类别
应用
(±)-4-Hydroxydebrisoquin sulfate can be used for the metabolic studies of debrisoquin.
生化/生理作用
CYP2D6 metabolite of debrisoquin.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
A Bozkurt et al.
Clinical pharmacology and therapeutics, 55(4), 399-401 (1994-04-01)
Debrisoquin hydroxylation polymorphism was studied in 326 unrelated healthy Turkish volunteers. Debrisoquin sulfate (10 mg) was administered to subjects, and debrisoquin and 4-hydroxydebrisoquin were determined in the 0- to 8-hour urine samples. Debrisoquin oxidation was polymorphic, with 11 subjects (3.37%;
Yueying Zhen et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(9), 1563-1574 (2006-06-20)
Considerable unexplained intersubject variability in the debrisoquine metabolic ratio (urinary debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. We speculated that debrisoquine was converted to as yet undisclosed metabolites. Thirteen healthy young volunteers, nine CYP2D6*1 homozygotes [extensive metabolizers (EMs)] and four CYP2D6*4
G L Shaw et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 4(1), 41-48 (1995-01-01)
Previous reports of the association between the debrisoquine metabolic polymorphism and lung cancer risk have been conflicting. We examined the hypothesis that the genetically determined ability to metabolize debrisoquine identifies individuals at increased risk for lung cancer in a study
M Lanz et al.
Electrophoresis, 18(10), 1875-1881 (1998-02-12)
Using capillary zone electrophoresis with a phosphate buffer at pH 2.5 containing 50 mM heptakis-(2,3,6-tri-O-methyl)-beta-CD as chiral selector, the separation of the enantiomers of the main metabolite of debrisoquine (DEB), 4-hydroxydebrisoquine (4-OHDEB), is reported. For extraction of underivatized urinary DEB
S C Mitchell et al.
Human & experimental toxicology, 13(8), 537-541 (1994-08-01)
Liver transplantation or the surgical construction of portacaval shunts may radically alter an individual's debrisoquine hydroxylation capacity. Good clinical management should encompass a full awareness of such changing needs and problems in patients who undergo hepatic surgery.
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