UC304
O -去甲基曲马多
别名:
2-[（二甲氨基）甲基]-1-（3-羟基苯基）环己醇, O -去甲基曲马多
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关于此项目
经验公式（希尔记法）:
C15H23NO2
化学文摘社编号:
分子量:
249.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Form:
solid
form
solid
storage temp.
2-8°C
SMILES string
CN(C)C[C@H]1CCCC[C@]1(O)c2cccc(O)c2
InChI
1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3/t13-,15+/m1/s1
InChI key
UWJUQVWARXYRCG-HIFRSBDPSA-N
General description
O-去甲基曲马多是一种阿片类药物，同时也是曲马多的活性代谢物。其生产的关键酶是多态性细胞色素P450同工酶2D6（CYP2D6）。
Application
O -去甲基曲马多已用于曲马多代谢物在山羊体内的药代动力学研究 。
O-去甲基曲马多可用作阿片类药物，用于测试其对人类自然杀伤细胞的细胞毒性功能的影响。它也可用作气相色谱-质谱法（GC-MS）中的内标物，用于定量测定人尿液样品中的曲马多衍生物。
Biochem/physiol Actions
O-去甲基曲马多对阿片受体具有高亲和力，并导致μ阿片受体的镇痛作用。
曲马多的代谢产物
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
flash_point_f
Not applicable
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Michael K Herbert et al.
BMC pharmacology, 7, 5-5 (2007-03-21)
Inhibition of intestinal peristalsis is a major side effect of opioid analgesics. Although tramadol is an opioid-like analgesic, its effect on gut motility is little known. Therefore, the effect of (+)-tramadol, (-)-tramadol and the major metabolite O-desmethyltramadol on intestinal peristalsis
Mendel Jansen et al.
Clinical pharmacology in drug development, 7(6), 597-612 (2018-06-06)
Four randomized, double-blind, placebo-controlled, 4-period drug-drug interaction studies were conducted in healthy subjects to evaluate the pharmacokinetic and pharmacodynamic (PD) interactions between mirogabalin and commonly used central nervous system depressants. Mirogabalin or placebo was administered alone or with single-dose lorazepam
Dermot P Maher et al.
Anesthesia and analgesia, 128(5), 1013-1021 (2019-02-26)
The use of regional and other opioid-sparing forms of anesthesia has been associated with a decrease in the recurrence of certain malignancies. Direct suppression of human natural killer cells by opioids has been postulated to explain this observation. However, the
A B de Sousa et al.
Journal of veterinary pharmacology and therapeutics, 31(1), 45-51 (2008-01-08)
The aim of this trial was to implement a method to obtain a tool for analyses of tramadol and the main metabolite, o-desmethyltramadol (M1), in goat's plasma, and to evaluate the pharmacokinetics of these substances following intravenous (i.v.) and oral
Marc Luginbühl et al.
Drug testing and analysis, 12(8), 1126-1134 (2020-05-13)
The World Anti-Doping Agency (WADA) and the International Testing Agency (ITA) recently announced the development and implementation of dried blood spot (DBS) testing for routine analysis in time for the 2022 Winter Olympic and Paralympic Games in Beijing. Following the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| UC304-5MG | 04061837410239 |
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