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UC305

O-Desmethylnaproxen

Name: <I>O</I>-Desmethylnaproxen
Brand: SIGMA

别名:

(S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid, d-2-(6-Hydroxy-2-naphthyl)proprionic acid

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₂O₃

化学文摘社编号:

52079-10-4

分子量:

216.23

UNSPSC Code:

12161501

NACRES:

NA.77

PubChem Substance ID:

329827666

MDL number:

MFCD00869765

Beilstein/REAXYS Number:

8838512

Form:

solid

Quality level:

200

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form

solid

Quality Level

200

color

white

mp

182-183 °C

storage temp.

2-8°C

SMILES string

C[C@H](C(O)=O)c1ccc2cc(O)ccc2c1

InChI

1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1

InChI key

XWJUDDGELKXYNO-QMMMGPOBSA-N

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Application

O-Desmethylnaproxen can be used for assaying naproxen metabolites.

Biochem/physiol Actions

CYP2C9 metabolite of naproxen

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H317,H400

pcodes

P273 - P280 - P301 + P312 + P330 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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分析证书(COA)

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Determination of naproxen and its metabolite O-desmethylnaproxen with their acyl glucuronides in human plasma and urine by means of direct gradient high-performance liquid chromatography.

T B Vree et al.

Journal of chromatography, 578(2), 239-249 (1992-07-24)

Naproxen is metabolized in humans by O-demethylation, and by acyl glucuronidation to the 1-O-glucuronide. Naproxen, its metabolite and the conjugates can be measured directly by gradient high-performance liquid chromatographic analysis without enzymic deglucuronidation. The glucuronide conjugates were isolated by preparative

High-performance liquid chromatographic determination of 6-desmethylnaproxen sulfate in human plasma.

C H Kiang et al.

Journal of chromatography, 383(2), 449-455 (1986-12-19)

Naproxen metabolites interfere with certain bilirubin assays: elimination of interference by using a Roche bilirubin assay on the Hitachi 917 analyzer.

Amitava Dasgupta et al.

American journal of clinical pathology, 133(6), 878-883 (2010-05-18)

A recent report indicated significant interference of naproxen with total bilirubin measurement when using the Jendrassik and Grof method. We explored the possibility of avoiding this interference by using a different method. We observed that naproxen has no effect on

Hypoalbuminaemia and naproxen pharmacokinetics in a patient with rheumatoid arthritis.

F A Van den Ouweland et al.

Clinical pharmacokinetics, 11(6), 511-515 (1986-11-01)

Plasma concentration of furosemide versus specific gravity of urine in predicting dose of administration in race horses.

C E Uboh et al.

Research communications in chemical pathology and pharmacology, 77(2), 201-218 (1992-08-01)

This study was undertaken to determine the applicability of plasma concentration of furosemide and specific gravity (SG) of urine in regulating the use of furosemide administered 4 hours prior to race time in Exercise-Induced Pulmonary Hemorrhage (EIPH) race horses. Nonbleeders

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全球贸易项目编号

货号	GTIN
UC305-5MG	04061832932170
UC305-10MG	04061832932163

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