UC305
O-Desmethylnaproxen
别名:
(S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid, d-2-(6-Hydroxy-2-naphthyl)proprionic acid
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关于此项目
经验公式（希尔记法）:
C13H12O3
化学文摘社编号:
分子量:
216.23
Beilstein:
8838512
MDL编号:
UNSPSC代码:
12161501
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
颜色
white
mp
182-183 °C
储存温度
2-8°C
SMILES字符串
C[C@H](C(O)=O)c1ccc2cc(O)ccc2c1
InChI
1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1
InChI key
XWJUDDGELKXYNO-QMMMGPOBSA-N
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相关类别
应用
O-Desmethylnaproxen can be used for assaying naproxen metabolites.
生化/生理作用
CYP2C9 metabolite of naproxen
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
T B Vree et al.
British journal of clinical pharmacology, 35(5), 467-472 (1993-05-01)
1. The pharmacokinetics of 500 mg naproxen given orally were described in 10 subjects using a direct h.p.l.c. analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. 2. The mean elimination half-life of naproxen was 24.7 +/-
C H Kiang et al.
Drug metabolism and disposition: the biological fate of chemicals, 17(1), 43-48 (1989-01-01)
A new metabolite of naproxen, 6-desmethylnaproxen sulfate (6-DMNS), has been identified in plasma from normal and uremic subjects after oral administration of a single 500 mg dose of naproxen. Tentative identification was achieved by the finding of an increase in
J L Shimek et al.
Journal of pharmaceutical sciences, 71(4), 436-439 (1982-04-01)
An isocratic high-pressure liquid chromatographic method for the determination of naproxen and its desmethyl metabolite in human plasma is presented. A reversed-phase octadecylsilane column was utilized with a mobile phase consisting of 55% methanol and 45% 0.10 M acetate buffer
J V Andersen et al.
Journal of chromatography, 577(2), 362-365 (1992-06-10)
A high-performance liquid chromatographic method for the simultaneous determination of both enantiomers of naproxen and its metabolite 6-O-desmethylnaproxen has been developed. The separation is performed on a column containing alpha 1-acid glycoprotein as the chiral selector. The method has been
Da-Fang Zhong et al.
Acta pharmacologica Sinica, 24(5), 442-447 (2003-05-13)
The metabolites of naproxen produced by Cunninghamella species were isolated and identified, and further to compare the similarities between microbial transformation and mammalian metabolism. Naproxen was transformed by three strains of Cunninghammella species (Cunninghamella blakeslesna AS 3.153, Cunninghamella echinulata AS
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