UC305
O-Desmethylnaproxen
别名:
(S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid, d-2-(6-Hydroxy-2-naphthyl)proprionic acid
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关于此项目
经验公式（希尔记法）:
C13H12O3
化学文摘社编号:
分子量:
216.23
UNSPSC Code:
12161501
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
8838512
Form:
solid
Quality level:
form
solid
Quality Level
color
white
mp
182-183 °C
storage temp.
2-8°C
SMILES string
C[C@H](C(O)=O)c1ccc2cc(O)ccc2c1
InChI
1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1
InChI key
XWJUDDGELKXYNO-QMMMGPOBSA-N
Application
O-Desmethylnaproxen can be used for assaying naproxen metabolites.
Biochem/physiol Actions
CYP2C9 metabolite of naproxen
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
T B Vree et al.
Biopharmaceutics & drug disposition, 14(6), 491-502 (1993-08-01)
The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. The
H Yokoyama et al.
Human & experimental toxicology, 13(12), 831-838 (1994-12-01)
1. Rat liver microsomal suspension containing NADPH and MgCl2 was incubated at 37 degrees C with naproxen, a non-steroidal anti-inflammatory drug. Thiobarbituric acid reactive substances (TBA-RS), high molecular weight protein aggregates and fluorescent substances were formed in the microsomal suspension.
Stephanie Selke et al.
Journal of chromatography. A, 1217(3), 419-423 (2009-12-17)
O-desmethylnaproxen (2-(6-hydroxynaphthalen-2-yl)propanoic acid) was identified in 10 different water samples from Germany and Pakistan. In the Pakistan samples it was found in all samples, surface water and effluents, exhibiting estimated concentrations between 0.04 and 1.36 microg/L. In Germany it was
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| UC305-5MG | 04061832932170 |
| UC305-10MG | 04061832932163 |