UC305
O-Desmethylnaproxen
别名:
(S)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid, d-2-(6-Hydroxy-2-naphthyl)proprionic acid
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关于此项目
经验公式（希尔记法）:
C13H12O3
化学文摘社编号:
分子量:
216.23
UNSPSC Code:
12161501
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
8838512
InChI
1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1
SMILES string
C[C@H](C(O)=O)c1ccc2cc(O)ccc2c1
InChI key
XWJUDDGELKXYNO-QMMMGPOBSA-N
form
solid
color
white
mp
182-183 °C
storage temp.
2-8°C
Quality Level
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Application
O-Desmethylnaproxen can be used for assaying naproxen metabolites.
Biochem/physiol Actions
CYP2C9 metabolite of naproxen
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Kushari Bowalgaha et al.
British journal of clinical pharmacology, 60(4), 423-433 (2005-09-29)
To characterize the kinetics of S-naproxen ('naproxen') acyl glucuronidation and desmethylnaproxen acyl and phenolic glucuronidation by human liver microsomes and identify the human UGT isoform(s) catalysing these reactions. Naproxen and desmethylnaproxen glucuronidation were investigated using microsomes from six and five
Stephanie Selke et al.
Journal of chromatography. A, 1217(3), 419-423 (2009-12-17)
O-desmethylnaproxen (2-(6-hydroxynaphthalen-2-yl)propanoic acid) was identified in 10 different water samples from Germany and Pakistan. In the Pakistan samples it was found in all samples, surface water and effluents, exhibiting estimated concentrations between 0.04 and 1.36 microg/L. In Germany it was
Da-Fang Zhong et al.
Acta pharmacologica Sinica, 24(5), 442-447 (2003-05-13)
The metabolites of naproxen produced by Cunninghamella species were isolated and identified, and further to compare the similarities between microbial transformation and mammalian metabolism. Naproxen was transformed by three strains of Cunninghammella species (Cunninghamella blakeslesna AS 3.153, Cunninghamella echinulata AS
P L Walker et al.
Annals of clinical biochemistry, 24 ( Pt 2), 177-181 (1987-03-01)
Interference by naproxen in the spectrophotometric assay for urinary 5-hydroxyindoleacetic acid has been investigated. Gas chromatography-mass spectrometry demonstrated that ingestion of naproxen was associated with the production of four urinary components, unchanged drug and three metabolites, the major one being
T B Vree et al.
Biopharmaceutics & drug disposition, 14(6), 491-502 (1993-08-01)
The aim of this investigation was to assess the pharmacokinetics of naproxen in 10 human subjects after an oral dose of 500 mg using a direct HPLC analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. The
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