UC430
1′-Hydroxymidazolam
≥97% (HPLC), powder
别名:
8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine
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关于此项目
经验公式（希尔记法）:
C18H13ClFN3O
化学文摘社编号:
分子量:
341.77
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
产品名称
1′-Hydroxymidazolam,
form
powder
Quality Segment
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
white to off-white
storage temp.
2-8°C
SMILES string
OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12
InChI
1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2
InChI key
QHSMEGADRFZVNE-UHFFFAOYSA-N
General description
1′-Hydroxymidazolam is the metabolite of midazolam.
Application
1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.
CYP3A4 metabolite of midazolam.
Biochem/physiol Actions
1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| UC430-5MG | 04061837410253 |
| UC430-10MG | 04061837410246 |