UC431
4-Hydroxymidazolam
≥97% (HPLC), solid
别名:
8-Chloro-6-(2-fluorophenyl)-4-hydroxy-4H-imidazo[1,5a][1,4]bezodiazepine
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关于此项目
经验公式（希尔记法）:
C18H13ClFN3O
化学文摘社编号:
分子量:
341.77
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
产品名称
4-Hydroxymidazolam,
form
solid
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada
color
white to off-white
mp
186-187 °C
storage temp.
2-8°C
SMILES string
FC(C=CC=C1)=C1C2=NC(O)C3=CN=C(C)N3C4=C2C=C(Cl)C=C4
InChI
1S/C18H13ClFN3O/c1-10-21-9-16-18(24)22-17(12-4-2-3-5-14(12)20)13-8-11(19)6-7-15(13)23(10)16/h2-9,18,24H,1H3
InChI key
ZYISITHKPKHPKG-UHFFFAOYSA-N
Application
4′-Hydroxymidazolam can be used in cell biology studies. It can also be used for studying cell signaling and neuroscience.
Biochem/physiol Actions
4′-Hydroxymidazolam is the minor hydroxylated metabolite of Midazolam (MDZ). The product contributes in the pharmacological impact of MDZ.
CYP3A4 metabolite of midazolam.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Valérie Wauthier et al.
Experimental gerontology, 41(9), 846-854 (2006-08-08)
The effect of ageing on CYP3A2, a male specific isoform, was examined in adult (9 months) and senescent (24 months) male rats. A significant decrease (65%) of CYP3A2-related activity (midazolam oxidation) was observed in all senescent rats. Half of these
A Ghosal et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(9), 940-947 (1996-09-01)
Midazolam (MDZ) is metabolized in human liver microsomes by the cytochrome P450 (CYP) 3A subfamily to 1'-hydroxy (1'-OH) and 4-hydroxy (4-OH) metabolites. MDZ is metabolized in the rat primarily to 4-OH MDZ, 1'-OH MDZ, and 1',4-dihydroxy (1',4-diOH) MDZ. The kinetics
J C Gorski et al.
Biochemical pharmacology, 47(9), 1643-1653 (1994-04-29)
The capabilities of cytochrome P4503A4 (CYP3A4), CYP3A5, and fetal hepatic microsomes containing CYP3A7 to metabolize midazolam were investigated using human hepatic microsomes and purified CYP3A4 and CYP3A5. Under initial rate conditions and high substrate concentration (400 microM midazolam), variability among
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| UC431-5MG | 04061837410260 |