UC432
AAMU
别名:
5-Acetylamino-6-amino-3-methyluracil, N-(4-Amino-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)acetimide
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关于此项目
经验公式（希尔记法）:
C7H10N4O3
化学文摘社编号:
分子量:
198.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Form:
solid
form
solid
color
white to light pink
mp
≥305 °C
storage temp.
2-8°C
SMILES string
CN1C(=O)NC(N)=C(NC(C)=O)C1=O
InChI
1S/C7H10N4O3/c1-3(12)9-4-5(8)10-7(14)11(2)6(4)13/h8H2,1-2H3,(H,9,12)(H,10,14)
InChI key
POQOTWQIYYNXAT-UHFFFAOYSA-N
Application
CYP1A2 metabolite of caffeine
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M E Morris et al.
Clinical pharmacology and therapeutics, 46(3), 359-366 (1989-09-01)
Little is known regarding the biotransformation of drugs in Down's syndrome. In particular, there are no published studies that examine metabolic pathways such as N-acetylation, which can exhibit genetically-determined variability. The objective of the present investigation was to compare the
A J Kilbane et al.
Clinical pharmacology and therapeutics, 47(4), 470-477 (1990-04-01)
The human acetylation genotype was determined by measuring urinary caffeine metabolites by use of a modification of a previously published HPLC method. The problem of separation of 7-methylxanthine (7X) from 1-methyluric acid (IU) in urine extracts was achieved by adding
P Wong et al.
Journal of pharmaceutical and biomedical analysis, 13(9), 1079-1086 (1995-08-01)
The ratio of 5-acetylamino-6-amino-3-methyluracil (AAMU) to 1-methylxanthine (1X) in urine samples after caffeine ingestion can be used to indicate human N-acetyltransferase (NAT2) phenotypes. In previous studies, this ratio has been determined by LC or capillary electrophoresis. The possibility that this
B K Tang et al.
Clinical pharmacology and therapeutics, 49(6), 648-657 (1991-06-01)
The use of two caffeine metabolite ratios for acetylator phenotyping was validated by demonstrating concordance with two sulfamethazine tests in 178 unrelated healthy subjects. The caffeine metabolites used for this purpose were 5-acetylamino-6-amino-3-methyluracil (AAMU), 1-methylxanthine (1X), and 1-methylurate (1U). The
Y Kawakubo et al.
Dermatology (Basel, Switzerland), 195(1), 43-45 (1997-01-01)
p-Phenylenediamine (PPD) has been widely distributed as hair dye ingredient and may be responsible for contact dermatitis. Since not all the subjects exposed to PPD react to the substance, we tested a possible predisposing factor of cutaneous drug metabolism. Eighty-five
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| UC432-5MG | 04061832932231 |
| UC432-10MG | 04061832932224 |
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