UC455
3-Cyano-7-ethoxycoumarin
≥97% (HPLC)
方案
≥97% (HPLC)
表单
solid
颜色
yellow to orange
储存温度
2-8°C
SMILES字符串
CCOc1ccc2C=C(C#N)C(=O)Oc2c1
InChI
1S/C12H9NO3/c1-2-15-10-4-3-8-5-9(7-13)12(14)16-11(8)6-10/h3-6H,2H2,1H3
InChI key
YAFGHMIAFYQSCF-UHFFFAOYSA-N
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一般描述
3-Cyano-7-ethoxycoumarin is a fluorescent substrate for Cytochrome P450 1A1 (CYP1A1), Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2C9 (CYP2C9) and Cytochrome P450 2C19 (CYP2C19).
应用
3-Cyano-7-ethoxycoumarin has been used as a substrate in cytochrome P (CYP) inhibition for fluorescence measurement.
生化/生理作用
Fluorescent probe useful in microsomal dealkylase studies.
Fluorescent probe useful in microsomal dealkylase studies. Typical drug-drug interactions resulting from enzyme inhibition.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
制备说明
3-Cyano-7-ethoxycoumarin is soluble in DMSO.
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Anima Ghosal et al.
Biopharmaceutics & drug disposition, 24(9), 375-384 (2003-12-23)
Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human cytochromes P450, human liver microsomes and human hepatocytes. Reproducible results were obtained using a fluorescent plate reader (CytoFluor) more
Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes
Ghosal A, et al.
Biopharmaceutics & Drug Disposition, 24(9), 375-384 (2003)
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Widespread resistance to first-line TB drugs is a major problem that will likely only be resolved through the development of new drugs with novel mechanisms of action. We have used structure-guided methods to develop a lead molecule that targets the
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Abeer ElKhoely et al.
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