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V0882

Sigma-Aldrich

D-Val-Leu-Lys 4-硝基苯胺 二盐酸盐

plasmin substrate

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别名:
D-Val-Leu-Lys-pNA 二盐酸盐, D-缬氨酰-L-亮氨酰-L-赖氨酸 4-硝基苯胺 二盐酸盐
经验公式（希尔记法）:
C23H38N6O5 · 2HCl
CAS号:
62354-43-2
分子量:
551.51
MDL编号:
MFCD00077899
PubChem化学物质编号:
24900701
NACRES:
NA.32

质量水平

200

检测方案

≥98% (TLC)

形式

powder

溶解性

water: 50 mg/mL, clear, colorless to yellow

储存温度

−20°C

SMILES字符串

Cl.Cl.CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C23H38N6O5.2ClH/c1-14(2)13-19(28-23(32)20(25)15(3)4)22(31)27-18(7-5-6-12-24)21(30)26-16-8-10-17(11-9-16)29(33)34;;/h8-11,14-15,18-20H,5-7,12-13,24-25H2,1-4H3,(H,26,30)(H,27,31)(H,28,32);2*1H/t18-,19-,20+;;/m0../s1

InChI key

VESQMNNSPPEOSZ-ZLARAOTRSA-N

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应用

D-Val-Leu-Lys 4-硝基苯胺二盐酸盐已被用作发色底物，以在酰胺分解活性测定和纤溶酶原活化测定中确定由纤溶酶原形成的纤溶酶。

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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M D Phaneuf et al.
Thrombosis and haemostasis, 71(4), 481-487 (1994-04-01)
In a continuing effort to create an agent which has both thrombolytic and antithrombotic properties, streptokinase (SK) was covalently bound to the potent antithrombin agent recombinant hirudin (rHir). Linkage of SK to 125I-rHir was accomplished via heterobifunctional crosslinkers in an
R Testa et al.
International journal of clinical & laboratory research, 29(3), 128-132 (1999-12-11)
Lipoprotein(a) levels are largely genetically determined and are linked to increased risk of coronary artery disease. The hypothesis that elevated lipoprotein(a) levels lead to decreased fibrinolysis, due to the close structural homology with plasminogen, could in part explain the genesis
L M Oliva et al.
Sangre, 43(3), 231-235 (1998-09-19)
A study was carried out to establish an appropriate method for streptokinase (SK) potency determination (biological assay) in order to fulfil the main function of the Instituto Nacional de Medicamentos respecting products marketed in Argentina. The potency of different commercial
M Yamada et al.
Veterinary research communications, 21(2), 75-84 (1997-02-01)
An active fraction that accelerates plasminogen activation by tissue-type plasminogen activator (t-PA) was purified from a haemolysate of bovine erythrocytes. When the haemolysate was mixed with t-PA, it produced a 2- to 3-fold increase in plasminogen activation as measured by
L C Petersen
European journal of biochemistry, 245(2), 316-323 (1997-04-15)
The two zymogens, plasminogen and pro-urokinase plasminogen activator (pro-uPA), constitute a system of reciprocal activation, since plasmin, generated by uPA-catalysed plasminogen activation, can activate pro-uPA to uPA. Two such zymogens, when mixed, will undergo autocatalytic, reciprocal activation resulting in generation
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实验方案

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride

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