V100
(±)-Vesamicol hydrochloride
>98%, solid
别名:
(±)-2-(4-Phenylpiperidino)cyclohexanol hydrochloride, AH-5183 hydrochloride
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关于此项目
经验公式（希尔记法）:
C17H25NO · HCl
化学文摘社编号:
分子量:
295.85
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
(±)-Vesamicol hydrochloride, >98%, solid
InChI
1S/C17H25NO.ClH/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14;/h1-3,6-7,15-17,19H,4-5,8-13H2;1H
SMILES string
Cl.OC1CCCCC1N2CCC(CC2)c3ccccc3
InChI key
XJNUHVMJVWOYCW-UHFFFAOYSA-N
assay
>98%
form
solid
color
white
solubility
aqueous buffers below pH 8: 1 mM
DMSO: soluble
ethanol: soluble
Gene Information
human ... SLC18A3(6572)
Biochem/physiol Actions
Potent inhibitor of vesicular acetylcholine storage.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Mee-Rye Park et al.
ChemSusChem, 13(17), 4455-4467 (2020-03-12)
There is strong interest in the valorization of lignin to produce valuable products; however, its structural complexity has been a conversion bottleneck. Chemical pretreatment liberates lignin-derived soluble fractions that may be upgraded by bioconversion. Cholinium ionic liquid pretreatment of sorghum
B A Bahr et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(7), 2267-2270 (1986-04-01)
Transport and storage of acetylcholine by purified Torpedo electric organ synaptic vesicles is blocked by the drug L-trans-2-(4-phenylpiperidino)cyclohexanol (AH-5183). This study sought evidence of a specific receptor for the drug. Highly tritiated L-trans-2-(4-phenyl [3,4-3H] piperidino)-cyclohexanol (L-[3H] AH5183) was synthesized. An
The vesicular acetylcholine transport system.
Marshall,L, et al.
Trends in Neurosciences, 10, 174-174 (1987)
C Prior et al.
General pharmacology, 23(6), 1017-1022 (1992-11-01)
1. Vesamicol (2-[4-phenylpiperidino] cyclohexanol) inhibits the transport of acetylcholine into synaptic vesicles in cholinergic nerve terminals. 2. Recent pharmacological studies of the effects of vesamicol on skeletal neuromuscular transmission have revealed a pattern of activity for the compound consistent with
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
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