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Merck
CN

V113

S(+)-γ-Vigabatrin

solid

别名:

S(+)-γ-Vinyl GABA, S(+)-4-Aminohexenoic acid

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关于此项目

经验公式(希尔记法):
C6H11NO2
化学文摘社编号:
分子量:
129.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
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Quality Level

form

solid

optical activity

[α]/D +11.8°, c = 2.5 in H2O(lit.)

color

off-white

solubility

ethanol: soluble, H2O: >20 mg/mL

storage temp.

2-8°C

SMILES string

N[C@@H](CCC(O)=O)C=C

InChI

1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m1/s1

InChI key

PJDFLNIOAUIZSL-RXMQYKEDSA-N

Application

S(+)-γ-Vigabatrin has been used as a standard in ultra-high-performance-liquid-chromatography (UHPLC).

Biochem/physiol Actions

γ-Vigabatrin has the potential to treat infantile spasms and seizures. It exhibits therapeutic effects against cocaine and other addictions.
GABA transaminase inhibitor; anti-convulsant.

Disclaimer

Hygroscopic


pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

STOT RE 1

target_organs

Eyes,Central nervous system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

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Evaluating risks for vigabatrin treatment
Krauss, Gregory L
Epilepsy currents, 9(5), 125-129 (2009)
Determination of enantiomeric vigabatrin by derivatization with diacetyl-l-tartaric anhydride followed by ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry
Zhao J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1040(5), 199-207 (2017)
O M Larsson et al.
Neuropharmacology, 25(6), 617-625 (1986-06-01)
A preferential effect of valproate on gamma-aminobutyric acid (GABA) in the nerve terminal compartment has been proposed. Gamma-vinyl GABA, an irreversible inhibitor of GABA-transaminase (GABA-T) causes a preferential increase in the GABA compartment of the non-nerve terminal. The aim of



全球贸易项目编号

货号GTIN
V113-5MG04061837429125