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Merck
CN

V1255

Sigma-Aldrich

D -缬氨酸

suitable for cell culture, BioReagent

别名:

D-α-氨基异戊酸, D-2-氨基-3-甲基丁酸

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About This Item

线性分子式:
(CH3)2CHCH(NH2)CO2H
CAS号:
分子量:
117.15
Beilstein:
1721135
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.75

生物来源

synthetic (organic)

质量水平

产品线

BioReagent

表单

powder

技术

cell culture | mammalian: suitable

mp

>295 °C (subl.) (lit.)

运输

ambient

储存温度

room temp

SMILES字符串

CC(C)[C@@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1

InChI key

KZSNJWFQEVHDMF-SCSAIBSYSA-N

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相关类别

一般描述

L-缬氨酸是一种必需的非极性氨基酸。D-缬氨酸是缬氨酸的非蛋白异构体。

应用

D-缬氨酸已用作下列培养基的补充剂:
  • 杜氏改良Eagle培养基(DMEM)/营养混合物F-12 Ham (F-12),用于小鼠肾近曲小管上皮细胞(RPTC)培养
  • 内皮细胞生长培养基MV2,用于大鼠肺微血管内皮细胞(RLMEC)培养
  • DMEM/F-12培养基,用于小鼠气管上皮细胞(MTEC)培养

生化/生理作用

D-缬氨酸适于半合成兽用抗生素、药物和农药等广泛生产应用。
D-缬氨酸在细胞培养中可用作细胞增殖的选择性抑制剂,主要抑制D-氨基酸氧化酶缺乏细胞。 D-缬氨酸一直以来均被用于抑制成纤维细胞生长,同时允许上皮细胞选择性生长。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
Elham Mohammadi et al.
Cell and tissue research, 362(3), 597-609 (2015-06-13)
Efficacy of therapeutic angiogenesis needs a comprehensive understanding of endothelial cell (EC) function and biological factors and cells that interplay with ECs. Stem cells are considered the key components of pro- and anti-angiogenic milieu in a wide variety of physiopathological
Hui Li et al.
PLoS pathogens, 14(1), e1006821-e1006821 (2018-01-05)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza
Phillip C Calder
The Journal of nutrition, 136(1 Suppl), 288S-293S (2005-12-21)
Although there has been great interest in the effects of amino acids on immune function, little is known about the impact of changes in BCAA availability on the ability of the immune system to function. Human immune cells incorporate BCAA

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