V1255
D -缬氨酸
BioReagent, suitable for cell culture
别名:
D-α-氨基异戊酸, D-2-氨基-3-甲基丁酸
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关于此项目
线性分子式:
(CH3)2CHCH(NH2)CO2H
化学文摘社编号:
分子量:
117.15
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
EC Number:
211-368-9
Beilstein/REAXYS Number:
1721135
MDL number:
产品名称
D -缬氨酸, BioReagent, suitable for cell culture
InChI
1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
InChI key
KZSNJWFQEVHDMF-SCSAIBSYSA-N
SMILES string
CC(C)[C@@H](N)C(O)=O
biological source
synthetic (organic)
product line
BioReagent
form
powder
technique(s)
cell culture | mammalian: suitable
mp
>295 °C (subl.) (lit.)
shipped in
ambient
storage temp.
room temp
Quality Level
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Application
D-缬氨酸已用作下列培养基的补充剂：
- 杜氏改良Eagle培养基(DMEM)/营养混合物F-12 Ham (F-12)，用于小鼠肾近曲小管上皮细胞(RPTC)培养
- 内皮细胞生长培养基MV2，用于大鼠肺微血管内皮细胞(RLMEC)培养
- DMEM/F-12培养基，用于小鼠气管上皮细胞(MTEC)培养
Biochem/physiol Actions
D-缬氨酸适于半合成兽用抗生素、药物和农药等广泛生产应用。
D-缬氨酸在细胞培养中可用作细胞增殖的选择性抑制剂，主要抑制D-氨基酸氧化酶缺乏细胞。 D-缬氨酸一直以来均被用于抑制成纤维细胞生长，同时允许上皮细胞选择性生长。
General description
L-缬氨酸是一种必需的非极性氨基酸。D-缬氨酸是缬氨酸的非蛋白异构体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
Hui Li et al.
PLoS pathogens, 14(1), e1006821-e1006821 (2018-01-05)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza
Elham Mohammadi et al.
Cell and tissue research, 362(3), 597-609 (2015-06-13)
Efficacy of therapeutic angiogenesis needs a comprehensive understanding of endothelial cell (EC) function and biological factors and cells that interplay with ECs. Stem cells are considered the key components of pro- and anti-angiogenic milieu in a wide variety of physiopathological
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
S F Gilbert et al.
Cell, 5(1), 11-17 (1975-05-01)
A nutrient medium has been developed to enable the growth of normal epithelial cells while selectively inhibiting fibroblast proliferation. In this medium, D-valine is substituted for L-valine; and only those cells containing D-amino acid oxidase can convert the D-amino acid
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