V2264

Vinorelbine ditartrate salt hydrate

Name: Vinorelbine ditartrate salt hydrate
Brand: SIGMA

≥98% (HPLC), powder

别名:

3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate

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经验公式（希尔记法）:

C₄₅H₅₄N₄O₈ · 2C₄H₆O₆ · xH₂O

化学文摘社编号:

125317-39-7

分子量:

1079.11 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24724660

UNSPSC Code:

12352200

MDL number:

MFCD03613607

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

主要文件

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产品名称

Vinorelbine ditartrate salt hydrate, ≥98% (HPLC), powder

color

off-white

InChI

1S/C45H54N4O8.2C4H6O6.H2O/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10;/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10);1H2/t28-,37-,38+,39+,42+,43+,44-,45-;2*1-,2-;/m011./s1

SMILES string

[H]O[H].O[C@H]([C@@H](O)C(O)=O)C(O)=O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@]12C[N@H](CC(CC)=C1)Cc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC

InChI key

ZLIPKSVXTCRHIB-GNBHHJMASA-N

assay

≥98% (HPLC)

form

powder

solubility

H₂O: 10 mg/mL

originator

Pierre Fabre

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Potent anti-mitotic, anti-tumor agent; inhibits microtubule assembly.

Vinorelbine is a potent anti-mitotic, anti-tumor agent. Vinorelbine inhibits microtubule assembly. Low neurotoxicity is related to its higher affinity for mitotic microtubules than for axonal microtubules.

Features and Benefits

This compound was developed by Pierre Fabre. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000445337

0000190919

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DT-13, a saponin monomer 13 of the Dwarf lilyturf tuber, synergized with vinorelbine to induce mitotic arrest via activation of ERK signaling pathway in NCI-H1299 cells.

Hongyang Li et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 89, 1277-1285 (2017-03-23)

Vinorelbine (NVB) is a semi-synthetic vinca alkaloid that is approved for the clinical therapy of lung cancer. However, the clinical application of NVB was limited because of the acquisition of resistance and inacceptable toxicity. Therefore, it is of great interest

What is the nonverbal communication of depression? Assessing expressive differences between depressive patients and healthy volunteers during clinical interviews.

Juliana Teixeira Fiquer et al.

Journal of affective disorders, 238, 636-644 (2018-06-30)

It is unclear if individuals with Major Depressive Disorder (MDD) present different nonverbal behavior (NVB) compared with healthy individuals, and also if depression treatments affect NVB. In this study, we compared the NVB of MDD subjects and healthy controls. We

Surgical Techniques for Managing Post-prostatectomy Erectile Dysfunction.

Fabio Castiglione et al.

Current urology reports, 18(11), 90-90 (2017-10-02)

Due to the increasing numbers of radical prostatectomies (RP) performed for prostate cancer, a substantial number of patients are now suffering from post-operative erectile dysfunction (ED). The aim of this study is to summarize the current literature on surgical techniques

Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity.

Lihui Wang et al.

Cell death & disease, 8(4), e2746-e2746 (2017-04-14)

Chemotherapeutic agents are generally used as a frontline therapy for non-small cell lung cancer (NSCLC). However, resistance to chemotherapy arises rapidly in NSCLC, and the reasons for chemotherapy resistance have not been fully determined. Here, we found cisplatin, but not

Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.

Vural Tagal et al.

Cancer research, 81(2), 400-413 (2020-11-12)

Polyploid giant cancer cells (PGCC) are common in tumors and have been associated with resistance to cancer therapy, tumor relapse, malignancy, immunosuppression, metastasis, cancer stem cell production, and modulation of the tumor microenvironment. However, the molecular mechanisms that cause these

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Vinorelbine ditartrate salt hydrate

≥98% (HPLC), powder

选择尺寸

关于此项目

主要文件

属性

产品名称

color

InChI

SMILES string

InChI key

assay

form

solubility

originator

shipped in

storage temp.

Quality Level

相关类别

说明

Biochem/physiol Actions

Features and Benefits

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

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