V3638
Vascular Endothelial Growth Factor 164 from rat
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
别名:
VEGF 164, VEGF-164, VEGF164, Vasculotropin
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关于此项目
Biological source:
rat
Recombinant:
expressed in NSO cells
Assay:
>95% (SDS-PAGE)
Form:
lyophilized powder
Mol wt:
dimer 50 kDa by SDS-PAGE, monomer 25 kDa by SDS-PAGE
Impurities:
endotoxin, tested
产品名称
Vascular Endothelial Growth Factor 164 from rat, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
biological source
rat
recombinant
expressed in NSO cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
1.08 ng/mL ED50
mol wt
dimer 50 kDa by SDS-PAGE, monomer 25 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
rat ... Vegfa(83785)
Application
Vascular Endothelial Growth Factor 164 (VEGF 164) from rat was used for cardiomyocytes culture and Ca2+ transients′ measurement. It was used as a medium M-199 supplement utilized in in vitro incubation for examining the capability of CTS to limit the impact of biologically relevant molecules, in particular epidermal growth factor (EGF), basic fibroblast growth factor (FGF2), and vascular endothelial growth factor A (VEGFA) in rat epididymis segment 1 and 2.
Biochem/physiol Actions
Mitogen for endothelial cells, enhances vascular permeability, activates, and chemoattracts monocytes and is a procoagulant.
Vascular Endothelial Growth Factor 164 also referred to as VEGF 164 or Vasculotropin is a growth factor that induces endothelial cell growth, vasculogenesis and angiogenesis. VEGF 164 can enhance collagen and fibronectin expression in mesangial cells which in turn stimulates TGF-β1-induced extracellular matrix. It also plays a pivotal role in progressive glomerular fibrosis.
Physical form
Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% TFA containing 0.5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells.
Other Notes
164 amino acid variant of rat VEGF.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
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Lin Wang et al.
The Journal of biological chemistry, 279(32), 33213-33219 (2004-05-15)
Transforming growth factor-beta1 (TGF-beta1) is a potent inducer of extracellular matrix synthesis leading to progressive glomerular fibrosis. The intracellular signaling mechanisms involved in this process remain incompletely understood. The p38 mitogen-activated protein kinase (MAPK) is a major stress signal transducing
C J Robinson et al.
Journal of cell science, 114(Pt 5), 853-865 (2001-02-22)
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商品
VEGF-A stimulates blood vessel growth via endothelial cell proliferation, migration, and survival during embryonic development.
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