V4512
Vascular Endothelial Growth Factor from mouse
≥98% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture
别名:
mVEGF, VEGF
产品名称
Vascular Endothelial Growth Factor from mouse, VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
powder
potency
≤10 ng/mL
quality
endotoxin tested
mol wt
protein 39 kDa
packaging
pkg of 10 μg
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
mouse ... VEGFA(22339)
Analysis Note
The biological activity is measured by the ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells.
Application
Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury.Vascular endothelial growth factor from mouse was used for ELISA and in matrigel plugs (matrigel was supplemented with VEGF).
General description
Vascular endothelial growth factor is also known as VPF, VEGF and MVCD1. It is secreted from endothelial cells and pericytes in response to hypoxia. It helps in inducing angiogenesis and microvascular hyperpermeability. VEGF levels are associated with vasculitic neuropathy and may be used to predict this disease. It may also act as a marker in the development and progression of early precancerous lesions of oesophagus.
Other Notes
Homodimeric protein consisting of two 165 amino acid polypeptide chains of mouse VEGF.
Physical form
Lyophilized from a 0.2 μm filtered buffered solution.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Katsuhisa Tashiro et al.
Stem cells and development, 23(18), 2202-2210 (2013-12-19)
Vascular endothelial growth factor (VEGF) is reported to exhibit potent hematopoietic stem/progenitor cell (HSPC) mobilization activity. However, the detailed mechanisms of HSPC mobilization by VEGF have not been examined. In this study, we investigated the effect of VEGF on bone
J Sundaram et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 690-700 (2014-07-01)
Recent studies have shown that factor VIIa binds to endothelial cell protein C receptor(EPCR), a cellular receptor for protein C and activated protein C. At present, the physiologic significance of FVIIa interaction with EPCR in vivo remains unclear. To investigate
Asieh Golozar et al.
European journal of cancer (Oxford, England : 1990), 50(16), 2855-2865 (2014-08-31)
Mechanisms involved in wound healing play some role in carcinogenesis in multiple organs, likely by creating a chronic inflammatory milieu. This study sought to assess the role of genetic markers in selected inflammation-related genes involved in wound healing (interleukin (IL)-1a
Benjamin B Bartelle et al.
Circulation research, 110(7), 938-947 (2012-03-01)
The formation and maintenance of a functional vasculature is essential for normal embryonic development, and genetic changes that affect the vasculature underlie pathogenesis in many human diseases. In vivo imaging in mouse models is required to understand the full complexity
Jafar Rezaie et al.
Journal of cellular biochemistry, 119(1), 524-535 (2017-06-14)
This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. Changes in the level of Ang-1, Ang-2, cell migration, and trans-differentiation into pericytes and endothelial
商品
VEGF-A stimulates blood vessel growth via endothelial cell proliferation, migration, and survival during embryonic development.
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