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V4515

VU0238429

Name: VU0238429
Brand: SIGMA

solubility: ≥20 mg/mL in DMSO

别名:

1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₂F₃NO₄

化学文摘社编号:

1160247-92-6

分子量:

351.28

NACRES:

NA.77

PubChem Substance ID:

329829052

UNSPSC Code:

12352200

MDL number:

MFCD16618396

Assay:

≥98% (HPLC)

Form:

powder

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属性

assay

≥98% (HPLC)

Quality Segment

100

form

powder

color

orange

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1

InChI

1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3

InChI key

CKLGZXFOLMHCMC-UHFFFAOYSA-N

说明

Biochem/physiol Actions

VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency.

VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.