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V5754

藜芦定

Name: 藜芦定
Brand: SIGMA

≥90% (HPLC), powder, Na+ channel opener

别名:

3-Veratroylveracevine, Veracevine veratrate

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关于此项目

经验公式（希尔记法）:

C₃₆H₅₁NO₁₁

化学文摘社编号:

71-62-5

分子量:

673.79

NACRES:

NA.77

PubChem Substance ID:

24900756

UNSPSC Code:

12352200

EC Number:

200-758-4

MDL number:

MFCD00082515

Beilstein/REAXYS Number:

78875

Assay:

≥90% (HPLC)

Form:

powder

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属性

产品名称

藜芦定, ≥90% (HPLC), powder

Quality Segment

100

assay

≥90% (HPLC)

form

powder

color

white to off-white

solubility

ethanol: 50 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1OC)C(=O)OC2CC[C@@]3(C)C4CCC5[C@]6(O)C[C@H](O)[C@@]7(O)C(CN8CC(C)CCC8[C@@]7(C)O)[C@]6(O)C[C@]35O[C@]24O

InChI

1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19?,23?,24?,25?,26?,27-,28?,30-,31+,32+,33+,34+,35-,36-/m0/s1

InChI key

FVECELJHCSPHKY-FCSYLLAHSA-N

说明

General description

Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.

Application

Veratridine has been used:

to record the veratridine-dependent increase in the late Na⁺ current using a HEK293 cell line stably transfected with human Na v1.5 24(4) to measure the ranolazine-induced inhibition of basal and veratridine-activated I Na late
to assess the effects of veratridine on action potentials (APs) in hiPSC-cardiomyocyte preparations externally paced in current-clamp mode
to study the inhibitory effects of veratridine on hERG1 current in stably transfected HEK293 cells
to treat neuroblastoma 2-a cells to improve sensitivity for N2a assay

Biochem/physiol Actions

Opens voltage-dependent Na⁺ channels and prevents their inactivation.

Opens voltage-dependent Na⁺ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.

Veratridine has been used as an insecticide, acting as a paralytic agent with higher toxicity to insects than to mammals.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300 + H310 + H330,H315,H319,H335,H361f,H373,H412

pcodes

P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Nervous system, Respiratory system

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c