V6383
长春西汀
≥98%, Ca²⁺-calmodulin-dependent phosphodiesterase I inhibitor, solid
别名:
(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester, Eburnamenine-14-carboxylic acid ethyl ester
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关于此项目
经验公式（希尔记法）:
C22H26N2O2
化学文摘社编号:
分子量:
350.45
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
产品名称
长春西汀, ≥98%, solid
质量水平
方案
≥98%
表单
solid
颜色
white
溶解性
DMSO: 5 mg/mL
H2O: insoluble
SMILES字符串
[H][C@]12N3CCC[C@@]1(CC)C=C(C(=O)OCC)n4c2c(CC3)c5ccccc45
InChI
1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
InChI key
DDNCQMVWWZOMLN-IRLDBZIGSA-N
基因信息
human ... PDE1A(5136), PDE1B(5153), PDE1C(5137)
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生化/生理作用
Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
免责声明
Photosensitive
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
A A Skoromets et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(4), 18-24 (2013-06-07)
Authors studied impairment of cognitive functions in 180 patients, aged 56-74 years, with chronic blood flow deficiency in the vertebrobasilar territory. Along with neurological examination, we used MRI of the brain and the cervical spine, MRI-angiography, ultrasound Doppler method, EEG
Klintsy Julieta Torres et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(3), 711-722 (2012-08-03)
In multiple sclerosis during periods of remission a limited degree of myelin repair can be observed mediated by oligodendroglial precursor cells. Phosphodiesterase inhibitors act as anti-inflammatory agents and might hold promise for future multiple sclerosis treatment. To investigate whether phosphodiesterase
M N Dadasheva et al.
Vestnik otorinolaringologii, (1)(1), 85-87 (2013-03-27)
The present paper is focused on the problem of etiology of sensorineural hearing impairment, approaches to its treatment, and actions to be taken by a physician to manage the disease. Sensorineural hearing impairment is considered to be a challenging socio-medical
Tomasz Sozański et al.
Pharmacological reports : PR, 63(5), 1258-1263 (2011-12-20)
Previous studies proved that food strongly enhanced the bioavailability of vinpocetine. Food may change the pharmacokinetics of a drug by affecting various factors, including gastrointestinal pH. However, the influence of proton pump inhibitor-induced pH alterations on vinpocetine pharmacokinetics is not
Alexei V Muravyov et al.
Clinical hemorheology and microcirculation, 49(1-4), 431-439 (2012-01-05)
This study was designed to evaluate hemorheological changes in patients with cerebrovascular disease (CVD) and peripheral arterial disease (PAD) after 4 weeks of pentoxifylline therapy as well as to study red blood cell microrheological variables after the cell incubation with
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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