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Merck
CN

V6879

Sigma-Aldrich

[Lys8]-Vasopressin

≥98% (HPLC)

别名:

Lysine vasopressin, Lyspressin

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关于此项目

经验公式（希尔记法）:
C46H65N13O12S2
化学文摘社编号:
50-57-7
分子量:
1056.22
EC 号:
200-050-5
MDL编号:
MFCD00133970
UNSPSC代码:
51111800
PubChem化学物质编号:
24900764
NACRES:
NA.32

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生物来源

synthetic (organic)

无菌性

non-sterile

方案

≥98% (HPLC)

表单

powder

溶解性

0.1 M acetic acid: 20 mg/mL, clear, colorless

UniProt登记号

P01185

运输

ambient

储存温度

−20°C

SMILES字符串

CC(O)=O.NCCCCC(NC(=O)C1CCCN1C(=O)C2CSSCC(N)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(Cc4ccccc4)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N2)C(=O)NCC(N)=O

InChI

1S/C46H65N13O12S2.C2H4O2/c47-17-5-4-9-29(40(65)52-22-38(51)63)54-45(70)35-10-6-18-59(35)46(71)34-24-73-72-23-28(48)39(64)55-31(20-26-11-13-27(60)14-12-26)43(68)56-32(19-25-7-2-1-3-8-25)42(67)53-30(15-16-36(49)61)41(66)57-33(21-37(50)62)44(69)58-34;1-2(3)4/h1-3,7-8,11-14,28-35,60H,4-6,9-10,15-24,47-48H2,(H2,49,61)(H2,50,62)(H2,51,63)(H,52,65)(H,53,67)(H,54,70)(H,55,64)(H,56,68)(H,57,66)(H,58,69);1H3,(H,3,4)

InChI key

NKWAIKZITYLOMT-UHFFFAOYSA-N

基因信息

human ... AVP(551)

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Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 [Disulfide Bridge: 1-6]

应用

[Lys8]-Vasopressin was used as a test compound in quantitative analysis of peptides and proteins by using on-line capillary isoelectric focusing-mass spectrometry.The product was used for studying the coupling of a polymer-based microchip electrophoresis to MALDI-TOF MS by using rotating ball interface.

生化/生理作用

Predominant form of vasopressin present in pigs and marsupials. It has lower vasopressor and antidiuretic activity than Arg8-vasopressin.
[Lys8]-Vasopressin also refers as Lysine vasopressin or Lyspressin is the predominant form of vasopressin present in pigs and marsupials. It antagonizes the amnesia in rats. Lyspressin can also induce resistance to extinction of active avoidance behaviour.

制备说明

2 mg of [Lys8]-Vasopressin dissolves in 0.1 mL, 0.1M HOAc to yield a clear, colorless solution.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000494140
0000494140
0000452499
0000452466
0000452466

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Yukihiro Kuroda et al.
Journal of pharmaceutical and biomedical analysis, 37(3), 423-428 (2005-03-03)
On-line capillary isoelectric focusing-mass spectrometry (cIEF-MS) was applied to determine concentrations of peptides and proteins using angiotensin II and human tetrasialo-transferrin as the model samples. The concentration of the carrier ampholyte was optimized for both resolution and ion intensity. cIEF-MS
Y-Y Huang et al.
The Journal of international medical research, 40(5), 1735-1744 (2012-12-05)
To investigate the presence of aquaporin (AQP) 1 and AQP2 in kidneys of cirrhotic rats with ascites, and to determine the effect of terlipressin on AQP1 and AQP2 levels and its therapeutic efficacy in ascites treatment. Eighteen rats were randomly
Elsa Solà et al.
Current opinion in organ transplantation, 18(3), 265-270 (2013-05-09)
Hepatorenal syndrome (HRS) is a dreaded complication of end-stage liver disease. The best treatment option for HRS is liver transplantation (LT) in suitable candidates. Pretransplant care of HRS is of utmost importance in order to secure a good posttransplant outcome.
Ornella Piazza et al.
Clinical transplantation, 26(6), E571-E575 (2012-11-06)
Metabolic management of brain-death organ donors includes correction of the hormonal perturbations that occur after cerebral death and impair circulatory function. Vasopressin is a hormone secreted by the posterior pituitary gland, which contributes to maintain systemic blood pressure by regulating
M Radicioni et al.
Journal of perinatology : official journal of the California Perinatal Association, 32(11), 893-895 (2012-11-07)
Experience with terlipressin (TP) in the neonatal field is scarce. We describe the effects of TP on pulmonary circulation, studied with echocardiography, in an asphyxiated septic cooled infant with pulmonary hypertension (PH) who developed catecholamine-resistant hypotension and exacerbation of PH
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