V8261
(±)-Vigabatrin
别名:
(R,S)-4-氨基-5-己烯酸, (±)-γ-乙烯基-GABA, (±)-4-氨基己酸
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关于此项目
经验公式（希尔记法）:
C6H11NO2
化学文摘社编号:
分子量:
129.16
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
创始人
Lundbeck
SMILES字符串
NC(CCC(O)=O)C=C
InChI
1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
InChI key
PJDFLNIOAUIZSL-UHFFFAOYSA-N
基因信息
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相关类别
生化/生理作用
不可逆的 GABA 转氨酶抑制剂。增加神经末梢的胞内 GABA 浓度；具有抗癫痫活性。
特点和优势
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Danger
危险声明
危险分类
STOT RE 1
靶器官
Eyes,Central nervous system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
R S Fisher
Brain research. Brain research reviews, 14(3), 245-278 (1989-07-01)
The study of mechanisms of the epilepsies requires employment of animal models. Choice of a model system depends upon several factors, including the question to be studied, the type of epilepsy to be modelled, familiarity and convenience. Over 50 models
Olga Doszyn et al.
iScience, 27(6), 110149-110149 (2024-07-01)
Mechanistic target of rapamycin complex 1 (mTORC1) is an integration hub for extracellular and intracellular signals necessary for brain development. Hyperactive mTORC1 is found in autism spectrum disorder (ASD) characterized by atypical reactivity to sensory stimuli, among other symptoms. In
The potential value of a negative finding: an illustrative example.
Kenneth Silverman et al.
JAMA psychiatry, 70(6), 571-572 (2013-04-12)
Mi-Sun Yum et al.
Journal of child neurology, 28(3), 308-313 (2012-07-04)
Tuberous sclerosis complex is a genetic disorder resulting in epilepsy and mental retardation. Vigabatrin has shown efficacy in the treatment of infantile spasms caused by tuberous sclerosis complex, but its effects on focal seizures caused by tuberous sclerosis complex have
Dorota Nieoczym et al.
Progress in neuro-psychopharmacology & biological psychiatry, 39(1), 129-135 (2012-06-12)
Sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, has recently been reported to affect convulsant activity in some animal models of seizures and epilepsy. Moreover, its influence on the protective activity of some antiepileptic drugs (AEDs) was also noted. The aim
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DISCOVER Bioactive Small Molecules for Neuroscience
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