V8379
Human Vitronectin
from human plasma, powder, suitable for cell culture
别名:
血清扩散因子
产品名称
玻连蛋白 来源于人类血浆, lyophilized powder, BioReagent, suitable for cell culture
生物来源
human plasma
质量水平
产品线
BioReagent
表单
lyophilized powder
分子量
A subunit 75 kDa
B subunit 65 kDa
包装
pkg of 50 μg
技术
cell culture | mammalian: suitable
表面覆盖度
0.1 μg/cm2
溶解性
water: soluble 0.050 mg/mL, clear, colorless
UniProt登记号
运输
ambient
储存温度
2-8°C
基因信息
human ... VTN(7448)
应用
玻连蛋白可用于具有整联蛋白受体(与玻连蛋白结合)的细胞,包括血小板、内皮细胞、黑素瘤细胞和骨肉瘤。推荐将其作为细胞培养基质成分,浓度为 0.1 μg/cm2。附着的最佳条件取决于细胞系和具体应用。
生化/生理作用
玻连蛋白结合糖胺聚糖,作为补体系统的细胞溶解攻击复合物的一种抑制剂,在凝血过程中与凝血酶和抗凝血酶 III 相互作用,并可能在凝血途径中发挥作用。
制备说明
该产品作为细胞培养物检测的冻干品(来自缓冲盐水)。由于玻连蛋白对亲水表面具有强亲和力,建议在操作过程中使用聚丙烯容器。每瓶产品可以重悬于 1mL 水中。然后应使用 0.2μm 膜对储备溶液进行过滤灭菌,等分并冷冻以便长期保存。
其他说明
玻连蛋白是一种存在于血浆和组织中的糖蛋白,并且是血浆中与纤连蛋白结合的主要细胞粘附蛋白之一。玻连蛋白的 N-末端残基与生长调节素 B 相同,随后的序列是与特定细胞表面受体相互作用的 R-G-D 序列。玻连蛋白的中心结构域富含疏水残基。C 末端附近是富含精氨酸的区域,具有肝素结合活性。
免责声明
供研究使用在法国,在用于科研目的时(包括进口和出口活动(《公共健康法》第L 1211-1条,第2节))该产品为管制品。购买者(即最终用户)需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
该冻干品应在 2-8℃ 下干燥储存。在这些条件下,它可以稳定至少 2 年。等分试样应储存在 -20°C 或 -70°C,但应避免反复冻融。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
Theodora Chatzisideri et al.
Journal of medicinal chemistry, 65(1), 271-284 (2021-12-31)
c(RGDyK)-based conjugates of gemcitabine (GEM) with the carbonate and carbamate linkages in the 6-OH group of GEM were synthesized for the targeted delivery of GEM to integrin αvβ3, overexpressing cancer cells to increase the stability as well as the tumor
The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.
Margheri F, Luciani C, Taddei ML, et al.
Oncotarget, 5(6), 1538-1553 (2014)
Lorenzo Baldini et al.
Molecules (Basel, Switzerland), 27(4) (2022-02-26)
During tumor angiogenesis different growth factors, cytokines and other molecules interact closely with each other to facilitate tumor cell invasion and metastatic diffusion. The most intensively studied as molecular targets in anti-angiogenic therapies are vascular endothelial growth factor (VEGF) and
Lacey M Field et al.
Journal of phycology, 54(2), 299-303 (2017-12-19)
Vitronectin (Vn) is a glycoprotein that serves a wide variety of roles in multicellular organisms. It was first identified in multicellular animals but has also been isolated from land plants and some algae, where it appears to serve as an
Francesca Posa et al.
Biomaterials, 267, 120484-120484 (2020-11-04)
Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle arrays carrying single BMP-2 dimers are prepared
商品
3D cell culture overview. Learn about 2D vs 3D cell culture, advantages of 3D cell culture, and techniques available to develop 3D cell models
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
3D细胞培养概述。了解2D与3D细胞培养的对比结果,3D细胞培养的优势以及可用于开发3D细胞模型的技术
培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持