V9389
Violacein
from Janthinobacterium lividum, >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC), powder, bacterial metabolite
产品名称
Violacein from Janthinobacterium lividum, >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
SMILES string
N1C(=C\C(=C4/c5c(cccc5)NC/4=O)\C1=O)c2c3c([nH]c2)ccc(c3)O
InChI
1S/C20H13N3O3/c24-10-5-6-15-12(7-10)14(9-21-15)17-8-13(19(25)23-17)18-11-3-1-2-4-16(11)22-20(18)26/h1-9,21,24H,(H,22,26)(H,23,25)/b18-13-
InChI key
XAPNKXIRQFHCHN-AQTBWJFISA-N
assay
>98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)
solubility
H2O: insoluble
acetone: soluble
ethanol: soluble
methanol: soluble
storage temp.
2-8°C
Quality Level
Application
Violacein from Janthinobacterium lividum has been used:
- for cell culture assays
- as a standard to determine the crude violacein concentration in ethanol extracts of D. violaceinigra str. NI28 cultures
- as a standard to identify violacein in the leaf samples of Nicotiana
Biochem/physiol Actions
Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities.
Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, transcription of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.
General description
Violacein from Janthinobacterium lividum is used as a colorant for natural and synthetic fabrics. It functions as a respiratory pigment and regulates tryptophan production. Violacein exhibits anti-protozoal activity.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Joaquin Atalah et al.
Extremophiles : life under extreme conditions, 24(1), 43-52 (2019-07-22)
Violacein is an intensely purple pigment synthesized by various genera of bacteria that has been discovered to have a wide range of interesting biological activities which range from anticarcinogenic to antibacterial. One of the hindrances for its real-life application is
Jerneja Ambrožič Avguštin et al.
Antonie van Leeuwenhoek, 103(4), 763-769 (2012-11-30)
A bacterial strain designated JA-1, related to Janthinobacterium lividum, was isolated from glacier ice samples from the island Spitsbergen in the Arctic. The strain was tested for phenotypic traits and the most prominent appeared to be the dark red brown
Recent research advances on Chromobacterium violaceum
Kothari V, et al.
Asian Pacific Journal of Tropical Biomedicine, 10(8), 744-752 (2017)
A robust gene-stacking method utilizing yeast assembly for plant synthetic biology
Shih PM, et al.
Nature Communications, 7, 13215-13215 (2016)
Microbial Production of Violacein and Process Optimization for Dyeing Polyamide Fabrics With Acquired Antimicrobial Properties
Kanelli M, et al.
Frontiers in Microbiology, 9 (2018)
商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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