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Merck
CN

V9879

Sigma-Aldrich

[Arg8]-Vasopressin acetate salt

synthetic (organic), ≥95% (HPLC), vasopressin receptor agonist, powder

别名:

β-Hypophamine, AVP, Antidiuretic hormone, Arginine vasopressin

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关于此项目

经验公式（希尔记法）:
C46H65N15O12S2 · xC2H4O2
CAS Number:
113-79-1
分子量:
1084.23 (free base basis)
EC 号:
204-035-4
MDL编号:
MFCD00133939
UNSPSC代码:
51111800
PubChem化学物质编号:
24900773
NACRES:
NA.32

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Product Name

[Arg8]-Vasopressin acetate salt, ≥95% (HPLC)

生物来源

synthetic (organic)

质量水平

200

无菌性

non-sterile

方案

≥95% (HPLC)

表单

powder

溶解性

water: 20.0-20.8 mg/mL, clear, colorless to faintly yellow

UniProt登记号

P01185
P30518
P37288
P47901

运输

ambient

储存温度

−20°C

SMILES字符串

CC(O)=O.N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O

InChI

1S/C46H65N15O12S2.C2H4O2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25;1-2(3)4/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53);1H3,(H,3,4)/t27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1

InChI key

ZHFGXNMADRRGQP-HPILINOVSA-N

基因信息

human ... AVP(551), AVPR1A(552), AVPR1B(553), AVPR2(554)

Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

一般描述

Arginine vasopressin is a nonapeptide. It is produced by anterior hypothalamus nerve cells.

应用

[Arg8]-Vasopressin acetate salt has been:
  • used as a vasopressin receptor agonist to test vasopressin receptors
  • used to evoke peripheral V1a receptor-mediated vasoconstriction
  • as a supplement in Ham′s F12/Dulbecco′s modified Eagle′s medium for proximal tubule and glomerular explant cell culture

生化/生理作用

Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg8-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).
Endogenous antidiuretic hormone in most mammalian species; neurotransmitter in the central nervous system implicated in a variety of physiological processes including diuresis, vasoregulation, and memory.

制备说明

[Arg8]-Vasopressin acetate salt dissolves water at 20 mg/ml to yield a clear colorless to faint yellow solution.

其他说明

Lyophilized from 0.5% acetic acid

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000415136
0000415136
0000360315
0000374016
0000284575

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Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice
Masuki S, et al.
The Journal of Physiology, 591(14), 3651-3665 (2013)
Daniel J van Wamelen et al.
Sleep, 36(1), 117-125 (2013-01-05)
To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus. Postmortem cohort study. Eight patients with HD and eight control subjects matched for sex
Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury
Szczypka MS, et al.
Stem Cells, 23(1), 44-54 (2005)
Medical Physiology, 424-424 (2009)
Shann Ménard et al.
Physiology & behavior, 208, 112577-112577 (2019-06-14)
The neuropeptides oxytocin (OT) and vasopressin (AVP) are critical in the formation of pair bonding in the vole, and potentially in other species. The finding that normally promiscuous male rats display a conditioned ejaculatory preference (CEP) for females that bear
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