V9889
伐昔洛韦 盐酸盐 水合物
≥98% (HPLC), solid
别名:
2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride, L-Valine, Valtrex
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关于此项目
经验公式（希尔记法）:
C13H20N6O4 · HCl · xH2O
化学文摘社编号:
分子量:
360.80 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white
溶解性
H2O: >20 mg/mL
抗生素抗菌谱
viruses
作用机制
DNA synthesis | interferes
储存温度
room temp
SMILES字符串
O.Cl.CC(C)[C@H](N)C(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12
InChI
1S/C13H20N6O4.ClH.H2O/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H;1H2/t8-;;/m0../s1
InChI key
KNOVZDRKHSHEQN-JZGIKJSDSA-N
生化/生理作用
Valacyclovir hydrochloride hydrate is a potent inhibitor of viral DNA polymerase.
Valacyclovir hydrochloride hydrate is potent inhibitor of viral DNA polymerase. It is a prodrug of acyclovir that is useful in viral, AIDS, and immune system regulation research.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Leigh Zerboni et al.
Journal of virology, 87(5), 2791-2802 (2012-12-28)
The tropism of herpes simplex virus (HSV-1) for human sensory neurons infected in vivo was examined using dorsal root ganglion (DRG) xenografts maintained in mice with severe combined immunodeficiency (SCID). In contrast to the HSV-1 lytic infectious cycle in vitro
Shin-ichi Sasaki et al.
The British journal of ophthalmology, 97(4), 498-503 (2013-01-31)
To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis. Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined.
S P Alexopoulos et al.
Current medicinal chemistry, 19(35), 5957-5963 (2012-09-12)
Human Cytomegalovirus is a commonly identified herpesvirus that establishes a state of latent infection in the majority of the population by adulthood. A coordinated immune response involving both the innate and adaptive immune system prevents active viral replication and disease.
Tomas Reischig et al.
Journal of the American Society of Nephrology : JASN, 23(9), 1588-1597 (2012-08-25)
Prevention of cytomegalovirus (CMV) is essential in organ transplantation. The two main strategies are pre-emptive therapy, in which one screens for and treats asymptomatic CMV viremia, and universal antiviral prophylaxis. We compared these strategies and examined long-term outcomes in a
Charlotte A Easton-Jones et al.
Journal of veterinary internal medicine, 32(5), 1763-1767 (2018-09-18)
Equine herpesvirus-5 is commonly isolated from the lungs of horses with EMPF, suggesting an etiological link. Valacyclovir is used empirically to treat EMPF; however, no data is available concerning its impact on EHV-5 viral kinetics. To determine the effect of
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