V9889
伐昔洛韦 盐酸盐 水合物
≥98% (HPLC), solid
别名:
2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl ester monohydrochloride, L-Valine, Valtrex
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关于此项目
经验公式（希尔记法）:
C13H20N6O4 · HCl · xH2O
化学文摘社编号:
分子量:
360.80 (anhydrous basis)
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white
溶解性
H2O: >20 mg/mL
抗生素抗菌谱
viruses
作用机制
DNA synthesis | interferes
储存温度
room temp
SMILES字符串
O.Cl.CC(C)[C@H](N)C(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12
InChI
1S/C13H20N6O4.ClH.H2O/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H;1H2/t8-;;/m0../s1
InChI key
KNOVZDRKHSHEQN-JZGIKJSDSA-N
生化/生理作用
Valacyclovir hydrochloride hydrate is a potent inhibitor of viral DNA polymerase.
Valacyclovir hydrochloride hydrate is potent inhibitor of viral DNA polymerase. It is a prodrug of acyclovir that is useful in viral, AIDS, and immune system regulation research.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
S P Alexopoulos et al.
Current medicinal chemistry, 19(35), 5957-5963 (2012-09-12)
Human Cytomegalovirus is a commonly identified herpesvirus that establishes a state of latent infection in the majority of the population by adulthood. A coordinated immune response involving both the innate and adaptive immune system prevents active viral replication and disease.
Shin-ichi Sasaki et al.
The British journal of ophthalmology, 97(4), 498-503 (2013-01-31)
To determine the efficacy of a new helicase-primase inhibitor, ASP2151, for treating herpetic keratitis. Murine corneas were infected with herpes simplex virus type 1 (HSV-1). ASP2151 was administered orally or topically, and the severity of epithelial dendritic keratitis was determined.
Leigh Zerboni et al.
Journal of virology, 87(5), 2791-2802 (2012-12-28)
The tropism of herpes simplex virus (HSV-1) for human sensory neurons infected in vivo was examined using dorsal root ganglion (DRG) xenografts maintained in mice with severe combined immunodeficiency (SCID). In contrast to the HSV-1 lytic infectious cycle in vitro
Charlotte A Easton-Jones et al.
Journal of veterinary internal medicine, 32(5), 1763-1767 (2018-09-18)
Equine herpesvirus-5 is commonly isolated from the lungs of horses with EMPF, suggesting an etiological link. Valacyclovir is used empirically to treat EMPF; however, no data is available concerning its impact on EHV-5 viral kinetics. To determine the effect of
Laura K Aguilar et al.
Current treatment options in oncology, 13(4), 437-450 (2012-08-21)
Glioblastoma multiforme (GBM) is the most common primary malignant tumor of the central nervous system (CNS) and one of the most lethal cancers in adults and children. Despite aggressive treatment with surgery, radiation, and chemotherapy, median survival is less than
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