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W0641

W-84 dibromide

Name: W-84 dibromide
Brand: SIGMA

≥98% (HPLC), solid

别名:

Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide

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关于此项目

经验公式（希尔记法）:

C₃₂H₄₄Br₂N₄O₄

化学文摘社编号:

21093-51-6

分子量:

708.52

NACRES:

NA.77

PubChem Substance ID:

24724665

UNSPSC Code:

12352202

MDL number:

MFCD00209827

Assay:

≥98% (HPLC)

Form:

solid

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属性

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~11 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

[Br-].[Br-].C[N+](C)(CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN3C(=O)c4ccccc4C3=O

InChI

1S/C32H44N4O4.2BrH/c1-35(2,23-13-19-33-29(37)25-15-7-8-16-26(25)30(33)38)21-11-5-6-12-22-36(3,4)24-14-20-34-31(39)27-17-9-10-18-28(27)32(34)40;;/h7-10,15-18H,5-6,11-14,19-24H2,1-4H3;2*1H/q+2;;/p-2

InChI key

DZRJZDQAGMZGGA-UHFFFAOYSA-L

说明

Biochem/physiol Actions

Potent allosteric modulator of M₂ muscarinic acetylcholine receptors.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

035K4610

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Allosteric effects of the alkane-bis-ammonium compound W84 and of tacrine on [3H]pirenzepine binding at M1-receptors in rat cerebral cortex.

K Mohr et al.

Pharmacology & toxicology, 75(6), 391-394 (1994-12-01)

The bis-quaternary W84, hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)-ammonium bromide], is a potent allosteric modulator of M2-cholinoceptors. In this study we aimed at quantifying its allosteric effect on the dissociation of [3H]pirenzepine from M1-cholinoceptors in rat cerebral cortex and to measure the effects on association

Comparison of structurally different allosteric modulators of muscarinic receptors by self-organizing neural networks.

U Holzgrabe et al.

Journal of molecular graphics, 14(4), 185-193 (1996-08-01)

Similarities in the molecular structure and surface properties of the allosteric modulators of muscarinic receptors, alcuronium, gallamine, tubocurarine, and the hexamethonium compound W84, a well-known pharmacological tool, are explored. The analysis of the molecular electrostatic potential (MEP) as well as

Interaction of Mg2+ with the allosteric site of muscarinic M2 receptors.

U Burgmer et al.

Naunyn-Schmiedeberg's archives of pharmacology, 357(4), 363-370 (1998-05-30)

Mg2+-ions have been suspected to attenuate the inhibitory effect of allosteric modulators on the dissociation of orthosteric ligands from muscarinic M2 receptors. It was aimed to gain more insight into the molecular events underlying the effect of Mg2+. The interaction

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全球贸易项目编号

货号	GTIN
W0641-10MG	04061832094311