W0769
汉黄芩素 水合物
≥98% (HPLC), solid
别名:
5,7-二羟基-8-甲氧基黄酮
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关于此项目
经验公式（希尔记法）:
C16H12O5 · xH2O
化学文摘社编号:
分子量:
284.26 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
XLCSETHCROERAU-UHFFFAOYSA-N
SMILES string
O.COc1c(O)cc(O)c2C(=O)C=C(Oc12)c3ccccc3
InChI
1S/C16H12O5.H2O/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9;/h2-8,17,19H,1H3;1H2
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
Quality Level
General description
汉黄芩素是从黄芩根提取的一种黄酮类化合物。
Application
汉黄芩素水合物可用于增强奥沙利铂对胃癌细胞和斑马鱼移植瘤模型的细胞毒性以及检测其对成熟3T3-L1脂肪细胞脂联素表达和分泌的影响。
Biochem/physiol Actions
Wogonin 是一种抗炎药和 COX-2 抑制剂，可抑制 iNOS 和 COX-2 的诱导。
Wogonin 是一种抗炎药和 COX-2 抑制剂，可抑制 iNOS 和 COX-2 的诱导。Wogonin 抑制 COX-2（IC50 = 46 μM）而不影响 COX-1。Wogonin 抑制 iNOS 诱导，从而抑制激活诱导的 C6 胶质细胞死亡。具体而言，Wogonin 抑制 NF-κB 介导的 iNOS 诱导。
汉黄芩素可与化疗药物奥沙利铂协同使用，增强其对胃癌细胞的诱导凋亡和抗肿瘤作用。它还能提高氟尿嘧啶和紫杉醇的疗效。汉黄芩素的抗氧化功能可用于治疗神经退行性疾病和炎症。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Matthew F Cusick et al.
Journal of virology, 87(3), 1849-1860 (2012-12-14)
Viral infections of the central nervous system (CNS) can trigger an antiviral immune response, which initiates an inflammatory cascade to control viral replication and dissemination. The extent of the proinflammatory response in the CNS and the timing of the release
Chiu-Mei Lin et al.
The American journal of Chinese medicine, 40(2), 415-427 (2012-03-16)
Constitutive activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway occurs commonly in cancer cells and endothelial cells, and contributes to angiogenesis. Wogonin is a compound with many biologically relevant properties. We previously reported that wogonin
Dae-Hee Lee et al.
Cellular signalling, 24(11), 2216-2225 (2012-08-01)
We investigated the molecular basis of the ability of wogonin to control the intracellular signaling cascades of AMP-activated protein kinase (AMPK). This activity induces antitumor activities in glioblastoma multiforme (GBM) cells. Recently, the evolutionarily conserved serine/threonine kinase AMPK has emerged
Tingqin Yan et al.
Diagnostic pathology, 9, 154-154 (2014-11-30)
Oxidative stress causes the defects of retinal pigment epithelial (RPE) cells that contribute to age-related macular degeneration (AMD). This study was conducted to determine whether wogonin could prevent H2O2-induced oxidative stress in RPE cells. A RPE cell line, ARPE-19, was
Hui-Ying Li et al.
Journal of biomedicine & biotechnology, 2012, 267890-267890 (2012-04-27)
This work is to study the baicalin and its three analogs, baicalin, wogonoside, and wogonin, on the protective effect of neuron from oxygen-glucose deprivation (OGD) and toll-like receptor 2 (TLR2) expression in OGD damage. The results showed that baicalin and
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