W1020
W146 水合物
≥98% (HPLC)
别名:
ML056, R-3-氨基-4-（3-己基苯氨基）-4-氧丁基膦酸水合物, [(3R)-3-氨基-4-[（3-己基苯基）氨基]-4-氧丁基]-膦酸
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关于此项目
经验公式（希尔记法）:
C16H27N2O4P · xH2O
化学文摘社编号:
分子量:
342.37 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
产品名称
W146 水合物, ≥98% (HPLC)
InChI key
DQKSZHVSROOTFY-XFULWGLBSA-N
SMILES string
O.CCCCCCc1cccc(NC(=O)[C@H](N)CCP(O)(O)=O)c1
InChI
1S/C16H27N2O4P.H2O/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22;/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22);1H2/t15-;/m1./s1
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
methanol: soluble (with 0.1% TFA)
originator
Novartis
storage temp.
2-8°C
Quality Level
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases (2014)
María V Simón et al.
Investigative ophthalmology & visual science, 56(10), 5808-5815 (2015-09-02)
Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular mediator and
The sphingosine-1-phosphate receptor-1 antagonist, W146, causes early and short-lasting peripheral blood lymphopenia in mice
Tarrason G, et al.
International Immunopharmacology, 11(11), 1773-1779 (2011)
Shahzad Nawaz Syed et al.
International journal of molecular sciences, 21(13) (2020-07-08)
Recent studies suggested an important contribution of sphingosine-1-phospate (S1P) signaling via its specific receptors (S1PRs) in the production of pro-inflammatory mediators such as Interleukin (IL)-1β in cancer and inflammation. In an inflammation-driven cancer setting, we previously reported that myeloid S1PR1
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1
Christensen PM, et al.
Faseb Journal, 30(6), 2351-2359 (2016)
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