W108
WAY-100635 马来酸盐
5-HT1A serotonin receptor antagonist, powder
别名:
N- [2- [4-（2-甲氧基苯基）-1-哌嗪基] 乙基]-N-2-吡啶基环己基甲酰胺 马来酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C25H34N4O2 · C4H4O4
化学文摘社编号:
分子量:
538.64
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
WAY-100635 马来酸盐, powder
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.COc1ccccc1N2CCN(CC2)CCN(C(=O)C3CCCCC3)c4ccccn4
InChI
1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
XIGAHNVCEFUYOV-BTJKTKAUSA-N
form
powder
color
white
solubility
H2O: 25 mg/mL
Quality Level
Gene Information
human ... HTR1A(3350)
相关类别
Application
WAY-100635马来酸盐已作为5-HT1A血清素受体拮抗剂用于：
- 研究清洁隆头鱼的行为是否受到5-羟色胺活性的调节
- 阻断3,4亚甲基二氧基甲基苯丙胺（MDMA）的活性，该酶可用于诱导雄性Wistar大鼠催产素释放，从而提高其社交行为
- 研究5-羟色胺在Phallusia mammillata海鞘幼虫变态中的作用
Biochem/physiol Actions
WAY-100635马来酸盐是一种高选择性 5-HT1A 5-羟色胺受体拮抗剂。它具有抑制依匹哌唑的能力，依匹哌唑是一种调节5-羟色胺-多巴胺活性的抗精神病药。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Mehdi Sekssaoui et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 49(4), 747-756 (2024-01-12)
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders in the world. First-line treatments such as selective serotonin reuptake inhibitors (SSRIs) still have many limitations, including a resistance to treatment in 30% of patients and a delayed
H Gozlan et al.
European journal of pharmacology, 288(2), 173-186 (1995-01-16)
The tritiated derivative of the novel silent 5-HT1A receptor antagonist WAY 100635 [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide] was tested as a potential radioligand of 5-HT1A receptors in the rat brain. Binding assays with membranes from various brain regions showed that [3H]WAY 100635
Naozumi Araragi et al.
Frontiers in pharmacology, 4, 97-97 (2013-08-13)
Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as anxiety disorders and depression, as well
Dopamine and serotonin modulate the onset of metamorphosis in the ascidian Phallusia mammillata
Zega G, et al.
Developmental Biology, 282(1), 246-256 (2005)
Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors
Yoshimi N, et al.
Pharmacology, Biochemistry, and Behavior, 124, 245-249 (2014)
实验方案
Foodstuffs often provide a challenge for the water determination by Karl-Fischer. Instant Coffee is such a sample matrix and its water content has influence on quality and shelf life.
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