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Merck
CN

W108

Sigma-Aldrich

WAY-100635 马来酸盐

5-HT1A serotonin receptor antagonist, powder

别名:

N- [2- [4-（2-甲氧基苯基）-1-哌嗪基] 乙基]-N-2-吡啶基环己基甲酰胺 马来酸盐

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关于此项目

经验公式（希尔记法）:
C25H34N4O2 · C4H4O4
化学文摘社编号:
634908-75-1
分子量:
538.64
MDL编号:
MFCD01321056
UNSPSC代码:
12352200
PubChem化学物质编号:
24278113
NACRES:
NA.77

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产品名称

WAY-100635 马来酸盐, powder

表单

powder

质量水平

100

颜色

white

溶解性

H2O: 25 mg/mL

SMILES字符串

[H]\C(=C(/[H])C(O)=O)C(O)=O.COc1ccccc1N2CCN(CC2)CCN(C(=O)C3CCCCC3)c4ccccn4

InChI

1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

XIGAHNVCEFUYOV-BTJKTKAUSA-N

基因信息

human ... HTR1A(3350)

相关类别

应用

WAY-100635马来酸盐已作为5-HT1A血清素受体拮抗剂用于：
  • 研究清洁隆头鱼的行为是否受到5-羟色胺活性的调节
  • 阻断3,4亚甲基二氧基甲基苯丙胺（MDMA）的活性，该酶可用于诱导雄性Wistar大鼠催产素释放，从而提高其社交行为
  • 研究5-羟色胺在Phallusia mammillata海鞘幼虫变态中的作用

生化/生理作用

WAY-100635马来酸盐是一种高选择性 5-HT1A 5-羟色胺受体拮抗剂。它具有抑制依匹哌唑的能力，依匹哌唑是一种调节5-羟色胺-多巴胺活性的抗精神病药。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000284068
0000284068
0000225757
0000225757
0000131217

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Mehdi Sekssaoui et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 49(4), 747-756 (2024-01-12)
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders in the world. First-line treatments such as selective serotonin reuptake inhibitors (SSRIs) still have many limitations, including a resistance to treatment in 30% of patients and a delayed
H Gozlan et al.
European journal of pharmacology, 288(2), 173-186 (1995-01-16)
The tritiated derivative of the novel silent 5-HT1A receptor antagonist WAY 100635 [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide] was tested as a potential radioligand of 5-HT1A receptors in the rat brain. Binding assays with membranes from various brain regions showed that [3H]WAY 100635
Naozumi Araragi et al.
Frontiers in pharmacology, 4, 97-97 (2013-08-13)
Firing activity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN) is controlled by inhibitory somatodendritic 5-HT1A autoreceptors. This autoinhibitory mechanism is implicated in the etiology of disorders of emotion regulation, such as anxiety disorders and depression, as well
Dopamine and serotonin modulate the onset of metamorphosis in the ascidian Phallusia mammillata
Zega G, et al.
Developmental Biology, 282(1), 246-256 (2005)
Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors
Yoshimi N, et al.
Pharmacology, Biochemistry, and Behavior, 124, 245-249 (2014)
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Water Determination in Instant Coffee by Karl Fischer Titration

Foodstuffs often provide a challenge for the water determination by Karl-Fischer. Instant Coffee is such a sample matrix and its water content has influence on quality and shelf life.

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