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W108

WAY-100635 马来酸盐

Name: WAY-100635 马来酸盐
Brand: SIGMA

5-HT1A serotonin receptor antagonist, powder

别名:

N- [2- [4-（2-甲氧基苯基）-1-哌嗪基] 乙基]-N-2-吡啶基环己基甲酰胺马来酸盐

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关于此项目

经验公式（希尔记法）:

C₂₅H₃₄N₄O₂ · C₄H₄O₄

化学文摘社编号:

634908-75-1

分子量:

538.64

UNSPSC Code:

12352200

PubChem Substance ID:

24278113

NACRES:

NA.77

MDL number:

MFCD01321056

Form:

powder

Quality level:

100

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属性

产品名称

WAY-100635 马来酸盐, powder

form

powder

Quality Level

100

color

white

solubility

H₂O: 25 mg/mL

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.COc1ccccc1N2CCN(CC2)CCN(C(=O)C3CCCCC3)c4ccccn4

InChI

1S/C25H34N4O2.C4H4O4/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21;5-3(6)1-2-4(7)8/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

XIGAHNVCEFUYOV-BTJKTKAUSA-N

Gene Information

human ... HTR1A(3350)

说明

Application

WAY-100635马来酸盐已作为5-HT1A血清素受体拮抗剂用于：

研究清洁隆头鱼的行为是否受到5-羟色胺活性的调节
阻断3,4亚甲基二氧基甲基苯丙胺（MDMA）的活性，该酶可用于诱导雄性Wistar大鼠催产素释放，从而提高其社交行为
研究5-羟色胺在Phallusia mammillata海鞘幼虫变态中的作用

Biochem/physiol Actions

WAY-100635马来酸盐是一种高选择性 5-HT1A 5-羟色胺受体拮抗剂。它具有抑制依匹哌唑的能力，依匹哌唑是一种调节5-羟色胺-多巴胺活性的抗精神病药。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000410128

0000284068

0000225757

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实验方案

Water Determination in Instant Coffee by Karl Fischer Titration

Foodstuffs often provide a challenge for the water determination by Karl-Fischer. Instant Coffee is such a sample matrix and its water content has influence on quality and shelf life.

3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner.

Elizabeth G Pitts et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(10), 1962-1971 (2017-04-21)

3,4-Methylenedioxymethamphetamine (MDMA) increases sociality in humans and animals. Release of serotonin (5-HT) is thought to have an important role in the increase in social behaviors, but the mechanisms underlying these effects are poorly understood. Despite the advantages of nonhuman primate

The role of serotonin in the modulation of cooperative behavior

Paula J, et al.

Behavioral ecology : official journal of the International Society for Behavioral Ecology, 26(4), 1005-1012 (2015)

Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist.

A Fletcher et al.

Behavioural brain research, 73(1-2), 337-353 (1996-01-01)

Although considerable progress has been made in characterising the 5-HT1A receptor using agonists, partial agonists or non-selective antagonists, further studies of 5-HT1A receptor function have been hindered by the lack of highly selective antagonists. The term 'silent' antagonist has been

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全球贸易项目编号

货号	GTIN
W108-25MG	04061835253609
W108-5MG	04061835253616