W109
S(–)-WIN 55,212-3 mesylate salt
solid
别名:
S(–)-[2,3-Dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt
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关于此项目
线性分子式:
C27H26N2O3 · CH3SO3H
化学文摘社编号:
分子量:
522.61
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
表单
solid
旋光性
[α]/D −48.0°, c = 0.246 in DMSO(lit.)
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
off-white
溶解性
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL
DMSO: soluble
methanol: soluble
SMILES字符串
CS(O)(=O)=O.Cc1c(C(=O)c2cccc3ccccc23)c4cccc5OC[C@H](CN6CCOCC6)n1c45
生化/生理作用
Inactive enantiomer of WIN 55,212-2.
法律信息
Manufactured and sold with the permission of Sterling Winthrop.
免责声明
吸湿
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
U Herzberg et al.
Neuroscience letters, 221(2-3), 157-160 (1997-01-17)
The effects of a high affinity cannabinoid receptor agonist were evaluated in rats subjected to chronic constriction injury of the sciatic nerve (CCI) or a sham operation. Intraperitoneal (i.p.) injections of the active, but not the inactive enantiomer, alleviated the
X Pan et al.
Molecular pharmacology, 49(4), 707-714 (1996-04-01)
Modulation of neuronal ion channels by the cloned rat brain CB1 cannabinoid receptor was investigated with the use of a heterologous neuronal expression system. Transient expression of the rat brain CB1 cannabinoid receptor was accomplished through microinjection of in vitro
A Richter et al.
European journal of pharmacology, 264(3), 371-377 (1994-11-03)
The effects of the novel high affinity cannabinoid receptor agonist (+)-WIN 55,212-2 ((R)-4,5-dihydro-2-methyl-4(4-morphoinylmethyl)-1-(1-naphthalen ylcarbonyl)-6H-pyrrolo[3,2,1-ij]quinolin-6-one) on severity of dystonia were investigated in mutant Syrian hamsters with primary generalized dystonia. Following injections of (+)-WIN 55,212-2 (1.0-5.0 mg/kg i.p.) a dose-dependent reduction of
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