W1520
WAY-200070
≥98% (HPLC)
别名:
7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol, 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
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关于此项目
经验公式（希尔记法）:
C13H8BrNO3
化学文摘社编号:
分子量:
306.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥20 mg/mL
originator
Wyeth
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1)-c2nc3cc(O)cc(Br)c3o2
InChI
1S/C13H8BrNO3/c14-10-5-9(17)6-11-12(10)18-13(15-11)7-1-3-8(16)4-2-7/h1-6,16-17H
InChI key
BAAILVWEAXFTSF-UHFFFAOYSA-N
General description
WAY-200070 is a potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs. 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.
Application
WAY-200070, a selective estrogen receptor-beta (ER-β) agonist, may be used in estrogen receptor signaling research along with other ERβ agonists [diarylpropionitrile (DPN)] and antagonist to help identify and differentiate the functions of estrogen receptor-beta(s) (ER-β) involved in processes such as regulation of the physiology of the endocrine pancreas; modulation of visceral pain; and stress response. WAY-200070 may be used to help establish that an observed physiological or cell signaling response is ER-β-dependent, especially versus ERα.
Biochem/physiol Actions
Potent, selective estrogen receptor-beta (ER-β) agonist (IC50 2.3 nM vs 155 nM for ER-α) with anxiolytic-like and antidepressant-like effects.
Features and Benefits
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Claus Lattrich et al.
Archives of gynecology and obstetrics, 289(1), 163-171 (2013-08-03)
Coexpression of estrogen receptors (ER) α and β is present in about half of all breast cancer cases. Whereas ERα is a well-established target for endocrine therapy with the selective estrogen receptor modulator tamoxifen, the applicability of ERβ as target
Lidia I Serova et al.
The Journal of endocrinology, 205(3), 253-262 (2010-03-30)
Previously, pretreatment with estradiol benzoate (EB) was found to modulate the response of hypothalamic-pituitary-adrenal (HPA) axis and gene expression in several catecholaminergic neuronal locations in ovariectomized (OVX) rats exposed to single immobilization stress (IMO). Here, we investigated the role of
Amy E Clipperton-Allen et al.
Psychoneuroendocrinology, 36(7), 981-995 (2011-01-21)
Gonadal hormones mediate both affiliative and agonistic social interactions. Research in estrogen receptor alpha (ERα) or beta (ERβ) knockout (KO) mice suggests that ERα increases and ERβ decreases male aggression, while the opposite is found for female ERαKO and ERβKO
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| W1520-25MG | 04061833227084 |
| W1520-5MG | 04061833227091 |